Listar por tema "Cytotoxic compounds"
Mostrando ítems 1-2 de 2
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Synthesis of combretastatin A-4 O-alkyl derivatives and evaluation of their cytotoxic, antiangiogenic and antitelomerase activity
Elsevier (2013-12)We here report the synthesis and biological evaluation of several combretastatin A-4 derivatives alkylated at the phenol hydroxyl group. Some of these derivatives contain an (E)-arylalkene fragment reminiscent of that ... -
The Mechanism of the Interactions of Pironetin Analog/Combretastatin A-4 Hybrids with Tubulin
Wiley (2015-06-17)We here report an investigation of the interactions with tubulin of two types of molecules of a hybrid structural type consisting in a combretastatin A-4 moiety and a simplified pironetin fragment. The cytotoxicities of ...