Listar por tema "Cysteine Proteases"
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Computational Studies of the Mechanism of Catalysis and Inhibition of Cysteine Proteases
Universitat Jaume I (2017-09-27)Falcipain-2 and cruzain are cysteine proteases involve in Malaria and Chagas disease. Today, many aspects of both, inhibition mechanism and catalytic mechanism of these enzymes are unclear. Thus, it is crucial to improve ... -
Synthetic studies on the preparation of alanyl epoxysulfones as cathepsin cysteine protease electrophilic traps
American Chemical Society (2015-07)A Darzens reaction between tert-butoxycarbonyl alaninal and chloromethyl phenyl sulfone afforded chlorohydrins, which were converted into epoxysulfones by reaction with sodium tert-butoxide. Epoxysulfone 10 and chloroketone ...