Listar por autoría "ed05d5ec-0b8b-4efe-9b92-a97a630e899d"
Mostrando ítems 1-4 de 4
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Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity
Gallego Villarejo, Lucia; Wallin, Cecilia; Król, Sylwia; Enrich Bengoa, Jennifer; Suades, Albert; Aguilella-Arzo, Marcel; Gómara Elena, María José; Haro, Isabel; Wärmlander, Sebastian; Muñoz, Francisco J.; Gräslund, Astrid; Perálvarez-Marín, Alex Elsevier (2022)Amyloid β-peptide (Aβ) misfolding into β-sheet structures triggers neurotoxicity inducing Alzheimer’s disease (AD). Molecules able to reduce or to impair Aβ aggregation are highly relevant as possible AD treatments since ... -
Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations
Perini, Deborah Aurora; Aguilella-Arzo, Marcel; Alcaraz, Antonio; Perálvarez-Marín, Alex; Queralt-Martín, María Elsevier (2021-12-16)Dynorphins are endogenous neuropeptides that function as ligands for the κ-opioid receptor. In addition to opioid activity, dynorphins can induce several pathological effects such as neurological dysfunctions and cell ... -
Experimental and computational biophysics to identify vasodilator drugs targeted at TRPV2 using agonists based on the probenecid scaffold
Catalina-Hernández, Èric; López-Martín, Mario; Masnou-Sánchez, David; Martins, Marco; Lorenz Fonfria, Victor A.; Jiménez-Altayó, Francesc; Hellmich, Ute A.; Inada, Hitoshi; Alcaraz, Antonio; Furutani, Yuji; Nonell-Canals, Alfons; Vázquez-ibar, José Luis; Domene, Carmen; Gaudet, Rachelle; Perálvarez-Marín, Alex Elsevier (2023-12-29)TRP channels are important pharmacological targets in physiopathology. TRPV2 plays distinct roles in cardiac and neuromuscular function, immunity, and metabolism, and is associated with pathologies like muscular dystrophy ... -
Structural biology workflow for the expression and characterization of functional human sodium glucose transporter type 1 in Pichia pastoris
Suades, Albert; Alcaraz, Antonio; Cruz, Esteban; Álvarez-Marimon, Elena; Whitelegge, Julian; Manyosa, Joan; Cladera, Josep; Perálvarez-Marín, Alex Nature Research (2019)Heterologous expression of human membrane proteins is a challenge in structural biology towards drug discovery. Here we report a complete expression and purification process of a functional human sodium/D-glucose co-transporter ...