Listar por autoría "d4a4cdbb-64f7-43e1-84c1-9a93a9b5c972"
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Evaluation of Mucociliary Clearance by Three Dimension Micro-CT-SPECTin Guinea Pig: Role of Bitter Taste Agonists
Ortiz, José L.; Ortiz, Amparo; MILARA, JAVIER; Armengot, Miguel; Sanz, Celia; Compañ, Desamparados; Morcillo, Esteban; Cortijo, Julio Public Library of Science (2016)Different image techniques have been used to analyze mucociliary clearance (MCC) in humans, but current small animal MCC analysis using in vivo imaging has not been well defined. Bitter taste receptor (T2R) agonists ... -
Non-neuronal cholinergic system contributes to corticosteroid resistance in chronic obstructive pulmonary disease patients
MILARA, JAVIER; Cervera, Angela; de Diego, Alfredo; Sanz, Celia; Juan, Gustavo; Gavaldà, Amadeu; Miralpeix, Montserrat; Morcillo, Esteban; Cortijo, Julio BioMed Central (2016)Background: Inhaled corticosteroid (ICS) with long-acting beta-2 agonists is a well-documented combination therapy for chronic obstructive pulmonary disease (COPD) based on its additive anti-inflammatory properties. By ... -
Paclitaxel Induces Epidermal Molecular Changes and Produces Subclinical Alterations in the Skin of Gynecological Cancer Patients
Montero, Paula; Pérez-Leal, Martín; Pérez-Fidalgo, J. Alejandro; Sanz, Celia; Estornut, Cristina; Roger, Inés; MILARA, JAVIER; Cervantes, Andrés; Cortijo, Julio MDPI (2022-03-01)Background: Paclitaxel is a microtubule-stabilizing chemotherapeutic agent. Despite its widespread use, it damages healthy tissues such as skin. The goal of this study was to prove that the real impact of paclitaxel-induced ... -
Paclitaxel-Induced Epidermal Alterations: An In Vitro Preclinical Assessment in Primary Keratinocytes and in a 3D Epidermis Model
Sanz, Celia; Montero, Paula; MILARA, JAVIER; Pérez-Leal, Martín; Estornut, Cristina; Roger, Inés; Pérez-Fidalgo, J. Alejandro; Cortijo, Julio MDPI (2022-01-22)Paclitaxel is a microtubule-stabilizing chemotherapeutic agent approved for the treatment of ovarian, non-small cell lung, head, neck, and breast cancers. Despite its beneficial effects on cancer and widespread use, ...