Listar por autoría "b4c2437d-bea4-4dc8-ad16-babe7705bb3d"
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Amino acid change in the carbohydrate response element binding protein is associated with lower triglycerides and myocardial infarction incidence depending on level of adherence to the Mediterranean diet in the PREDIMED trial
CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Estruch, Ramon; Asensio, Eva Maria; Coltell, Oscar; González, José I.; Martínez González, Miguel Ángel; Ros, Emilio; Salas-Salvadó, Jordi; Fitó, Montserrat; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Ruiz-Gutiérrez, Valentina; Gómez Gracia, Enrique; Fiol Ramis, Miquel; Flores, Gemma; Pintó, Xavier; Sáiz, Carmen; Ordovás Muñoz, José M.; Corella, Dolores American Heart Association (2014-02)Background: A variant (rs3812316, C771G, Gln241His) in the MLXIPL (Max-like protein X interacting protein-like) gene encoding the carbohydrate response element binding protein has been associated with lower triglycerides. ... -
Association between dietary fibre intake and fruit, vegetable or whole-grain consumption and the risk of CVD: results from the PREvención con DIeta MEDiterránea (PREDIMED) trial
Buil-Cosiales, Pilar; Toledo, Estefanía; Salas-Salvadó, Jordi; Zazpe, Itziar; Farràs, Marta; Basterra-Gortari, Francisco Javier; Díez Espino, Javier; Estruch, Ramon; Corella, Dolores; Ros, Emilio; Marti, Amelia; Gómez Gracia, Enrique; Ortega-Calvo, Manuel; Arós, Fernando; Moñino, Manuel; Serra-Majem, Lluis; Pintó, Xavier; Lamuela Raventós, Rosa María; Babio, Nancy; González, José I.; Fitó, Montserrat; Martínez González, Miguel Ángel Nutrition Society (2016)Prospective studies assessing the association between fibre intake or fibre-rich food consumption and the risk of CVD have often been limited by baseline assessment of diet. Thus far, no study has used yearly repeated ... -
Association of the LCT-13910C>T polymorphism with obesity and its modulation by dairy products in a Mediterranean population
Corella, Dolores; Arregui, María; Coltell, Oscar; Portolés, Olga; Guillem Sáiz, Patricia; Carrasco, Paula; Sorlí, José V; CAROLINA, ORTEGA-AZORÍN; González, José I.; Ordovás Muñoz, José M. Nature Publishing Group (2011-08)The -13910C>T polymorphism (rs4988235) upstream from the lactase (LCT) gene, strongly associated with lactase persistence (LP) in Europeans, is emerging as a new candidate for obesity. We aimed to analyze the association ... -
Associations between the New DNA-Methylation-Based Telomere Length Estimator, the Mediterranean Diet and Genetics in a Spanish Population at High Cardiovascular Risk
Coltell, Oscar; Asensio, Eva Maria; Sorlí, José V; Ortega-Azorín, Carolina; Fernandez Carrion, Rebeca; Pascual, Eva C.; Barragán-Arnal, Rocío; González, José I.; Estruch, Ramon; Alzate, Juan F.; Pérez-Fidalgo, J. Alejandro; Portolés, Olga; Ordovas, Jose M.; Corella, Dolores MDPI (2023-11)Biological aging is a relevant risk factor for chronic diseases, and several indicators for measuring this factor have been proposed, with telomere length (TL) among the most studied. Oxidative stress may regulate telomere ... -
Bitter, Sweet, Salty, Sour and Umami Taste Perception Decreases with Age: Sex-Specific Analysis, Modulation by Genetic Variants and Taste-Preference Associations in 18 to 80 Year-Old Subjects
Barragán-Arnal, Rocío; Coltell, Oscar; Portolés, Olga; Asensio, Eva Maria; Sorlí, José V; CAROLINA, ORTEGA-AZORÍN; González, José I.; Sáiz, Carmen; Fernández-Carrión, Rebeca; Ordovás Muñoz, José M.; Corella, Dolores MDPI (2018)There is growing interest in relating taste perception to diet and healthy aging. However, there is still limited information on the influence of age, sex and genetics on taste acuity as well as on the relationship between ... -
Candidate Gene and Genome-Wide Association Studies for Circulating Leptin Levels Reveal Population and Sex-Specific Associations in High Cardiovascular Risk Mediterranean Subjects
CAROLINA, ORTEGA-AZORÍN; Coltell, Oscar; Asensio, Eva Maria; Sorlí, José V; González, José I.; Portolés, Olga; Saiz, Carmen; Estruch, Ramon; Ramírez-Sabio, Judith B.; Pérez-Fidalgo, J. Alejandro; Ordovas, Jose; Corella, Dolores MDPI (2019)Leptin is a hormone crucial in the regulation of food intake and body-weight maintenance. However, the genes and gene variants that influence its plasma levels are still not well known. Results of studies investigating ... -
Education modulates the association of the FTO rs9939609 polymorphism with body mass index and obesity risk in the Mediterranean population
Corella, Dolores; Carrasco, Paula; Sorlí, José V; Coltell, Oscar; CAROLINA, ORTEGA-AZORÍN; Guillen, Montserrat; González, José I.; Sáiz, Carmen; Estruch, Ramon; Ordovás Muñoz, José M. Elsevier (2012)Objective To define whether the rs9939609 FTO (fat mass and obesity associated) single nucleotide polymorphism (SNP) is associated with anthropometric measurements and its modulation by educational level in a Mediterranean ... -
Genome-wide association analyses of weight loss in a randomized controlled trial of lifestyle intervention, and combined transcriptome-wide associations in a Mediterranean population
Corella, Dolores; Asensio, Eva Maria; CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Fernández-Carrión, Rebeca; Barragán-Arnal, Rocío; González, José I.; Coltell, Oscar European Molecular Biology Organization (EMBO) (2019-09-11)Although large-scale genome-wide association studies (GWAS) for obesity traits have identified more than 400 associated loci from observational studies (Figure 1), we highlight the fact that currently the number of GWAS ... -
Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population
Coltell, Oscar; Asensio, Eva Maria; Sorlí, José V; Barragán-Arnal, Rocío; Fernández-Carrión, Rebeca; Portolés, Olga; CAROLINA, ORTEGA-AZORÍN; Martínez-LaCruz, Raúl; González, José I.; Zanón-Moreno, Vicente; Gimenez Alba, Ignacio Manuel; Fitó, Montserrat; Ros, Emilio; Ordovás Muñoz, José M.; Corella, Dolores MDPI (2019)Although, for decades, increased serum bilirubin concentrations were considered a threatening sign of underlying liver disease and had been associated with neonatal jaundice, data from recent years show that bilirubin is ... -
Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary Modulation in Mediterranean Subjects with Metabolic Syndrome
Coltell, Oscar; Sorlí, José V; Asensio, Eva Maria; Barragán-Arnal, Rocío; González, José I.; Gimenez Alba, Ignacio Manuel; Zanón-Moreno, Vicente; Estruch, Ramon; Ramírez-Sabio, Judith B.; Pascual, Eva C.; CAROLINA, ORTEGA-AZORÍN; Ordovas, Jose; Corella, Dolores MDPI (2020)Many early studies presented beneficial effects of polyunsaturated fatty acids (PUFA) on cardiovascular risk factors and disease. However, results from recent meta-analyses indicate that this effect would be very low or ... -
Impact of the -1438G>A polymorphism in the serotonin 2A receptor gene on anthropometric profile and obesity risk: A case-control study in a Spanish Mediterranean population
Sorlí, José V; Francés, F.; González, José I.; Guillen, Montserrat; Portolés, Olga; Sabater, Antonio; Coltell, Oscar; Corella, Dolores (2008)Research into the genetic factors that regulate food intake is arousing great interest. The polymorphism -1438G>A in the serotonin 2A receptor or 5-hydroxytriptamine (5-HT) type 2A receptor (5-HTR2A) gene has been ... -
Mediterranean Diet Reduces the Adverse Effect of the TCF7L2-rs7903146 Polymorphism on Cardiovascular Risk Factors and Stroke Incidence
Corella, Dolores; Carrasco, Paula; Sorlí, José V; Estruch, Ramon; Rico Sanz, Jesús; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Covas Planells, María Isabel; Coltell, Oscar; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Ruiz-Gutiérrez, Valentina; Warnberg, Julia; Fiol Ramis, Miquel; Pintó, Xavier; CAROLINA, ORTEGA-AZORÍN; Muñoz, Miguel Ángel; Martínez, J. Alfredo; Gómez Gracia, Enrique; González, José I.; Ros, Emilio; Ordovás Muñoz, José M. American Diabetes Association (2013)OBJECTIVE Transcription factor 7-like 2 (TCF7L2) polymorphisms are strongly associated with type 2 diabetes, but controversially with plasma lipids and cardiovascular disease. Interactions of the Mediterranean diet (MedDiet) ... -
Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial
Corella, Dolores; Sorlí, José V; González, José I.; CAROLINA, ORTEGA-AZORÍN; Fitó, Montserrat; Bulló, Mònica; Martínez González, Miguel Ángel; Ros, Emilio; Arós, Fernando; Lapetra, José; Gómez Gracia, Enrique; Serra-Majem, Lluis; Ruiz-Gutiérrez, Valentina; Fiol Ramis, Miquel; Coltell, Oscar; Vinyoles, Ernest; Pintó, Xavier; Martí, Amelia; Sáiz, Carmen; Ordovás Muñoz, José M.; Estruch, Ramon BioMed Central (2014-01)Background: The Fas apoptotic pathway has been implicated in type 2 diabetes and cardiovascular disease. Although a polymorphism (rs7138803; G > A) near the Fas apoptotic inhibitory molecule 2 (FAIM2) locus has been related ... -
Single tube optimisation of APOE genotyping based on melting curve analysis
Francés, F.; Portolés, Olga; Sorlí, José V; Guillen, M.; González, José I.; Corella, Dolores Elsevier (2008)Objectives: To develop and validate a single-tube protocol for APOE genotyping using fluorescent probes. Design and methods: We have designed and validated a hybrid, single-tube, SimpleProbe/FRET probe protocol that takes ... -
The Gln241His polymorphism in the carbohydrate response element binding protein (MLXIPL) gene
CAROLINA, ORTEGA-AZORÍN; Carrasco, Paula; Sorlí, José V; Coltell, Oscar; Asensio, Eva Maria; Luna, C.; González, José I.; Corella, Dolores Nature Publishing Group (2009-06) -
Ultra-processed foods consumption as a promoting factor of greenhouse gas emissions, water, energy, and land use: A longitudinal assessment
García, Silvia; Pastor Martín, Rosario; Monserrat Mesquida, Margalida; Álvarez-Álvarez, Laura; Rubín-García, María; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Corella, Dolores; Fitó, Montserrat; Martínez, Alfredo J.; Tojal Sierra, Lucas; Wärnberg, Julia; Vioque, Jesus; Romaguera, Dora; López Miranda, José; Estruch, Ramon; Tinahones, Francisco J; Santos Lozano, José Manuel; Serra-Majem, Lluis; Cano-Ibáñez, Naomi; Pintó, Xavier; Delgado Rodríguez, Miguel; Matía-Martín, Pilar; Vidal, Josep; Vázquez, Clotilde; Daimiel, Lidia; Ros, Emili; Buil-Cosiales, Pilar; Martínez Rodríguez, María de los Ángeles; Coltell, Oscar; Castañer, Olga; GARCIA-RIOS, ANTONIO; Barceló, Concepción; Gómez-Gracia, Enrique; Zulet, María Ángeles; Konieczna, Jadwiga; Casas, Rosa; Massó, Paloma; Goicolea-Güemez, Leire; Bernal López, María Rosa; BES-RASTROLLO, MAIRA; Sangeetha, Shyam; González, José I.; Zomeño, Maria Dolors; Peña Orihuela, Patricia; González Palacios, Sandra; Toledo, Estefanía; Khoury, Nadine; Pérez-Vega, Karla Alejandra; Martín Sánchez, Vicente; Tur, Josep; Bouzas Velasco, Cristina Elsevier (2023)Background: Dietary patterns can produce an environmental impact. Changes in people's diet, such as the increased consumption of ultra-processed food (UPF) can not only influence human health but also environment ...