Listar por autoría "a18b4fe5-cc7b-45a4-9f83-ac0128523201"
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Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level
Ren, Weiwu; Pengelly, Robert; Farren-Dai, Marco; Shamsi Kazem Abadi, Saeideh; Oehler, Verena; Akintola, Oluwafemi; Draper, Jason; Meanwell, Michael; Chakladar, Saswati; Świderek, Katarzyna; Moliner, Vicent; Britton, Robert; Gloster, Tracey M.; Bennet, Andrew J. Nature Research (2018)Mechanism-based glycoside hydrolase inhibitors are carbohydrate analogs that mimic the natural substrate’s structure. Their covalent bond formation with the glycoside hydrolase makes these compounds excellent tools for ...