• openAccess   A genome-wide association study of attention function in a population-based sample of children 

      Alemany, Silvia; Vilor-Tejedor, Natalia; Bustamante, Mariona; Pujol, Jesús; Macià, Dídac; Martínez Vilavella, Gerard; Fenoll, Raquel; Alvárez-Pedrerol, Mar; Forns, Joan; Julvez, Jordi; Suades-González, Elisabet; Llop, Sabrina; Rebagliato, Marisa; Sunyer Deu, Jordi Public Library of Science (2016)
      Background Attention function filters and selects behaviorally relevant information. This capacity is impaired in some psychiatric disorders and has been proposed as an endophenotype for Attention-Deficit/Hyperactivity ...
    • openAccess   Ancient Haplotypes at the 15q24.2 Microdeletion Region Are Linked to Brain Expression of MAN2C1 and Children's Intelligence 

      Cáceres, Alejandro; Esko, Tonu; Pappa, Irene; Gutierrez, Armand; López Espinosa, María José; Llop, Sabrina; Bustamante, Mariona; Tiemeier, Henning; Metspalu, Andres; Joshi, Peter K.; Wilsonx, James F.; Reina Castillón, Judith; Shin, Jean; Pausova, Zdenka; Paus, Tomás; Sunyer Deu, Jordi; Perez-Jurado, Luis; González, Juan R. Anna Carla Goldberg, Hospital Israelita Albert Einstein, BRAZIL (2016)
      The chromosome bands 15q24.1-15q24.3 contain a complex region with numerous segmental duplications that predispose to regional microduplications and microdeletions, both of which have been linked to intellectual disability, ...
    • closedAccess   Association between exposure to organochlorine compounds and maternal thyroid status: Role of the iodothyronine deiodinase 1 gene 

      Llop, Sabrina; Murcia, Mario; Álvarez Pedrerol, Mar; Grimalt, Joan O.; SANTA MARINA, LORETO; Julvez, Jordi; Goñi-Irigoyen, Fernando; Espada, Mercedes; Ballester, Ferran; Rebagliato, Marisa; López Espinosa, María José Elsevier (2017-04-08)
      Introduction: Exposure to organochlorine compounds (OCs) may interfere with thyroid hormone (TH) homeostasis. The disruption of the deiodinase (DIO) enzymes has been proposed as a mechanism of action. Aim: To evaluate ...
    • openAccess   Distributions and determinants of urinary biomarkers of organophosphate pesticide exposure in a prospective Spanish birth cohort study 

      Llop, Sabrina; Murcia, Mario; Íñiguez, Carmen; Roca, Marta; González, Llúcia; Yusà, Vicent; Rebagliato, Marisa; Ballester, Ferran BioMed Central (2017)
      Background: Prenatal exposure to organophosphate pesticides (OPs) has been associated with impaired child development. Pesticide exposure determinants need to be studied in order to identify sources and pathways of pesticide ...
    • openAccess   Exposure to mercury among 9-year-old children and neurobehavioural function 

      Lozano, Manuel; Murcia, Mario; Soler-Blasco, Raquel; González Llúcia; Iriarte, Gorka; Rebagliato, Marisa; Lopez-Espinosa, Maria-Jose; Esplugues Cebrián, Ana; Ballester, Ferran; Llop, Sabrina Elsevier (2020-10-20)
      Mercury (Hg) is an environmental neurotoxicant whose main route of exposure in humans is the consumption of seafood. The aim of this study was to explore the relationship between Hg exposure at 9 years old and behaviour ...
    • closedAccess   Exposure to mercury among Spanish preschool children: Trend from birth to age four 

      Llop, Sabrina; Murcia, Mario; Aguinagalde, Xabier; Vioque, Jesus; Rebagliato, Marisa; Cases, Amparo; Iñiguez, Carmen; López Espinosa, María José; Amurrio, Ascensión; Navarrete-Muñoz, Eva María; Ballester, Ferran Elsevier (2014)
      The purpose of this study is to describe the total hair mercury concentrations and their determinants in preschool Spanish children, as well as to explore the trend in mercury exposure from birth to the age four. This ...
    • closedAccess   Gender differences in the neurotoxicity of metals in children 

      Llop, Sabrina; López Espinosa, María José; Rebagliato, Marisa; Ballester, Ferran Elsevier (2013-09)
      Gender-related differences in susceptibility to chemical exposure to neurotoxicants have not received sufficient attention. Although a significant number of epidemiological studies on the neurodevelopmental effects of metal ...
    • closedAccess   Iodine Supplementation During Pregnancy and Infant Neuropsychological: INMA Mother and Child Cohort Study 

      Rebagliato, Marisa; Murcia, Mario; Álvarez Pedrerol, Mar; Espada, Mercedes; Fernández Somoano, Ana; Lertxundi, Nerea; Navarrete-Muñoz, Eva María; Forns, Joan; Aranbarri, Aritz; Llop, Sabrina; Julvez, Jordi; Tardon, Adonina; Ballester, Ferran Oxford University Press (2013-04)
      Iodine supplementation during pregnancy is a common practice in developed countries. However, scant evidence is available regarding the safety and effectiveness of maternal iodine supplementation with regard to child ...
    • closedAccess   Maternal copper status and neuropsychological development in infants and preschool children 

      Amorós Salvador, Rubén; Murcia, Mario; González, Llúcia; Soler-Blasco, Raquel; Rebagliato, Marisa; Iñiguez, Carmen; Carrasco, Paula; Vioque, Jesus; Broberg, Karin; Levi, Michael; López Espinosa, María José; Ballester, Ferran; Llop, Sabrina Elsevier (2019-04)
      Introduction Copper (Cu) is an essential element involved in biological processes; however, excessive Cu could be harmful because of its reactive nature. Very few studies have evaluated its potential neurotoxic effects. ...
    • openAccess   Maternal iron status during pregnancy and attention deficit/hyperactivity disorder symptoms in 7-year-old children: a prospective cohort study 

      Díaz-López, Andrés; Canals, Josefa; Julvez, Jordi; Fernández-Barrés, Sílvia; Llop, Sabrina; Rebagliato, Marisa; Lertxundi, Nerea; SANTA MARINA, LORETO; Guxens, Mònica; Sunyer Deu, Jordi; Arija, Victoria Nature (2022)
      Evidence suggests that iron status may be linked to symptoms of childhood attention deficit/hyperactivity disorder (ADHD), but there is little data available on the relationship between iron status in pregnancy and the ...
    • openAccess   Polymorphisms in ABC Transporter Genes and Concentrations of Mercury in Newborns – Evidence from Two Mediterranean Birth Cohorts 

      Llop, Sabrina; Engström, Karin; Ballester, Ferran; Franforte, Elisa; Alhamdow, Ayman; Pisa, Federica; Tratnik, Janja Snoj; Mazej, Datja; Murcia, Mario; Rebagliato, Marisa; Bustamante, Mariona; Sunyer Deu, Jordi; Sofianou-Katsoulis, Aikaterini; Prasouli, Alexia; Antonopoulou, Eleni; Antoniadou, Ioanna; Nakou, Sheena; Barbone, Fabio; Horvat, Milena; Broberg, Karin Public Library of Science (2014)
      Background: The genetic background may influence methylmercury (MeHg) metabolism and neurotoxicity. ATP binding cassette (ABC) transporters actively transport various xenobiotics across biological membranes. Objective: ...
    • openAccess   Postnatal exposure to mercury and neuropsychological development among preschooler children 

      Llop, Sabrina; Murcia, Mario; Amorós Salvador, Rubén; Julvez, Jordi; SANTA MARINA, LORETO; Soler-Blasco, Raquel; Rebagliato, Marisa; Iñiguez, Carmen; Aguinagalde, Xabier; Iriarte, Gorka; Lopez-Espinosa, Maria-Jose; Andiarena, Ainara; Gonzalez, Llúcia; Vioque, Jesus; Sunyer Deu, Jordi; Ballester, Ferran Springer (2020-03-13)
      The objective of this study was to describe the postnatal exposure to Hg and to evaluate its association with neuropsychological development among preschool children. The study population are 4–5 years old children (n = ...
    • openAccess   Pre and postnatal exposure to mercury and respiratory health in preschool children from the Spanish INMA Birth Cohort Study 

      Carrasco, Paula; Estarlich, Marisa; Iñiguez, Carmen; Ferrero, Amparo; Murcia, Mario; Esplugues Cebrián, Ana; Vioque, Jesus; SANTA MARINA, LORETO; Zabaleta, Carlos; Iriarte, Gorka; Fernández Somoano, Ana; Tardon, Adonina; Vrijheid, Martine; Sunyer Deu, Jordi; Ballester, Ferran; Llop, Sabrina Elsevier (2021)
      Effects of mercury on maturing immune system have been reported, however the association with respiratory and allergy problems during infancy remains unclear. The aim of this study is to evaluate the association between ...
    • closedAccess   Prenatal and postnatal insecticide use and infant neuropsychological development in a multicenter birth cohort study 

      Llop, Sabrina; Julvez, Jordi; Fernández Somoano, Ana; SANTA MARINA, LORETO; Vizcaino, Esther; Iñiguez, Carmen; Lertxundi, Nerea; Gascón, Mireia; Rebagliato, Marisa; Ballester, Ferran Elsevier (2013)
      There is little evidence about exposure to currently used insecticides during early life periods and adverse effects on child neuropsychological development. The aim of this study is to examine the association between ...
    • closedAccess   Prenatal exposure to mercury and longitudinally assesssed fetal growth: Relation and effect modifiers 

      Ballester, Ferran; Íñiguez, Carmen; Murcia, Mario; Guxens, Mònica; Basterretxea, Mikel; Rebagliato, Marisa; Vioque, Jesus; Lertxundi, Aitana; Fernández Somoano, Ana; Tardon, Adonina; Sunyer Deu, Jordi; Llop, Sabrina Elsevier (2018-01)
      Background:Prenatal mercury exposure has been related to reductions in anthropometry at birth. Levels ofmercury have been reported as being relatively elevated in the Spanish population.Objective:To investigate the relation ...
    • closedAccess   Prenatal exposure to mercury and neuropsychological development in young children: the role of fish consumption 

      Llop, Sabrina; Ballester, Ferran; Murcia, Mario; Forns, Joan; Tardon, Adonina; Andiarena, Ainara; Vioque, Jesus; Ibarluzea, Jesus; Fernández Somoano, Ana; Sunyer Deu, Jordi; Julvez, Jordi; Rebagliato, Marisa; López Espinosa, María José Oxford University Press (2016-11)
      Background: Vulnerability of the central nervous system to mercury exposure is increased during early development. The aim of this study is to evaluate the association between prenatal exposure to mercury and child ...
    • closedAccess   Prenatal mercury exposure and birth outcomes 

      Murcia, Mario; Ballester, Ferran; Enning, Ashley Michel; Iñiguez, Carmen; Valvi, Damaskini; Basterretxea, Mikel; Rebagliato, Marisa; Vioque, Jesus; Maruri, Maite; Tardon, Adonina; Riaño, Isolina; Vrijheid, Martine; Llop, Sabrina Elsevier (2016-11)
      Background: Results regarding the association between mercury exposure and anthropometry at birth, gestational length and placental weight are inconsistent, as is the role of seafood intake in these asso- ciations. Objective: ...
    • closedAccess   Selenium status during pregnancy: Influential factors and effects on neuropsychological development among Spanish infants 

      Amorós Salvador, Rubén; Murcia, Mario; Ballester, Ferran; Broberg, Karin; Iñiguez, Carmen; Rebagliato, Marisa; Skröder, Helena; González, Llúcia; López Espinosa, María José; Llop, Sabrina Elsevier (2018)
      Selenium (Se) has been positively associated with neurodevelopment in early life. However, its margin of safety is rather narrow, and few prospective studies have evaluated its potential neurotoxic effects at intermediate ...
    • closedAccess   Synergism between exposure to mercury and use of iodine supplements on thyroid hormones in pregnant women 

      Llop, Sabrina; López Espinosa, María José; Murcia, Mario; Álvarez Pedrerol, Mar; Vioque, Jesus; Aguinagalde, Xabier; Julvez, Jordi; Aurrekoetxea, J. J.; Espada, Mercedes; SANTA MARINA, LORETO; Rebagliato, Marisa; Ballester, Ferran Elsevier (2015)
      To evaluate the association between mercury exposure and thyroid-stimulating hormone (TSH), total triiodothyronine (TT3) and free thyroxine (FT4) levels during pregnancy as well as to explore if there is any synergic action ...