Listar por autoría "51d1283d-5798-4723-aa46-ebdb8917540f"
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JAK2 mediates lung fibrosis, pulmonary vascular remodelling and hypertension in idiopathic pulmonary fibrosis: an experimental study
MILARA, JAVIER; Ballester, Beatriz; Morell, Anselm; Ortiz, José L.; Escrivá, Juan; Fernández, Estrella; Pérez-Vizcaino, Francisco; Cogolludo, Ángel; Pastor, Enrique; Artigues, Enrique; Morcillo, Esteban; Cortijo, Julio BMJ (2018)Background Pulmonary hypertension (PH) is a common disorder in patients with idiopathic pulmonary fibrosis (IPF) and portends a poor prognosis. Recent studies using vasodilators approved for PH have failed in improving IPF ... -
MUC4 is overexpressed in idiopathic pulmonary fibrosis and collaborates with transforming growth factor β inducing fibrotic responses
MILARA, JAVIER; Ballester, Beatriz; Safont, M. J.; Artigues, Enrique; Escrivá, Juan; Morcillo, Esteban; Cortijo, Julio Springer Nature (2020-09-04)Several mucins are implicated in idiopathic pulmonary fibrosis (IPF); however, there is no evidence regarding the role of MUC4 in the development of IPF. Here we demonstrated that MUC4 was overexpressed in IPF patients ... -
Mucin 1 deficiency mediates corticosteroid insensitivity in asthma
MILARA, JAVIER; Morell, Anselm; de Diego, Alfredo; Artigues, Enrique; Morcillo, Esteban; Cortijo, Julio Wiley (2019-01)BACKGROUND: The loss of corticosteroid efficacy is an important issue in severe asthma management and may lead to poor asthma control and deterioration of airflow. Recent data indicate that Mucin 1 (MUC1) membrane mucin ...