Listar por autoría "49059b9d-5bfe-4ee2-81ca-1f900e8d5512"
Mostrando ítems 1-6 de 6
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Aryl urea based scaffolds for multitarget drug discovery in anticancer immunotherapies
Martín Beltrán, Celia; Gil-Edo, Raquel; Hernández Ribelles, Germán; Agut, Raúl; Marí Mezquita, Pilar; Carda, Miguel; Falomir, Eva MDPI (2021-04-06)Twenty-one styryl and phenethyl aryl ureas have been synthetized and biologically evaluated as multitarget inhibitors of Vascular endothelial growth factor receptor-2 VEGFR-2 and programmed death-ligand-1 (PD-L1) proteins ... -
Synthesis and Antiproliferative Activity of 3 and 7-Styrylcoumarins
Herrera-R, Angie; Castrillón, Wilson; Otero, Elver; Ruiz, Esneyder; Carda, Miguel; Agut, Raúl; Naranjo Preciado, Tonny; Moreno, Gustavo; Maldonado, María Elena; Cardona Galeano, Wilson Isidro Springer Verlag (2018)A series of styrylcoumarins were obtained via Mizoroki-Heck reactions between 3-bromo-4-methyl7-(octyloxy)-2H-chromen-2-one or 2-oxo-2H-chromen-7-yl trifluoromethanesulfonate and functionalized styrenes. The structures ... -
Synthesis of Combretastatin A-4 and 3 0 -Aminocombretastatin A-4 derivatives with Aminoacid Containing Pendants and Study of their Interaction with Tubulin and as Downregulators of the VEGF, hTERT and c-Myc Gene Expression
Agut, Raúl; Falomir, Eva; Murga, Juan; Martín Beltrán, Celia; Gil Edo, Raquel; Pla, Alberto; Carda, Miguel; Marco, J. Alberto MDPI (2020)Natural product combretastatin A-4 (CA-4) and its nitrogenated analogue 3 0 -aminocombretastatin A-4 (AmCA-4) have shown promising antitumor activities. In this study, a range of CA-4 and AmCA-4 derivatives containing ... -
Synthesis, antiprotozoal activity and cytotoxicity in U-937 macrophages of triclosan–hydrazone hybrids
Vergara, Sebastián; Carda, Miguel; Agut, Raúl; Yepes, Lina M.; Vélez, Iván D.; Robledo, Sara M. Springer Verlag (2017)The synthesis and biological activities (cytotoxicity, leishmanicidal, and trypanocidal) of 11 triclosan–hydrazone hybrids are described herein. The structure of the products was elucidated by spectral data (NMR, IR) and ... -
Synthesis, leishmanicidal, trypanocidal and cytotoxic activities of quinoline-chalcone and quinoline-chromone hybrids
Coa, Juan Carlos; García, Elisa; Carda, Miguel; Agut, Raúl; Vélez, Iván D.; Muñoz, July A.; Yepes, Lina M.; Robledo, Sara M. Springer Verlag (2017)We report herein the synthesis and biological activities (cytotoxicity, leishmanicidal and trypanocidal) of six quinoline-chalcone and five quinoline-chromone hybrids. The synthesized compounds were evaluated against ... -
Triclosan-caffeic acid hybrids: Synthesis, leishmanicidal, trypanocidal and cytotoxic activities
Otero, Elver; García, Elisa; Palacios, Génesis; Yepes, Lina M.; Carda, Miguel; Agut, Raúl; Vélez, Iván D.; Cardona Galeano, Wilson Isidro; Robledo, Sara M. Elsevier (2017-09-29)The synthesis, cytotoxicity, anti-leishmanial and anti-trypanosomal activities of twelve triclosan-caffeic acid hybrids are described herein. The structure of the synthesized products was elucidated by a com- bination ...