Listar por autoría "0498cfce-9609-45ac-9367-2b1b5c31b0cb"
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Experimental and Computational Studies Delineate the Role of Asparagine 177 in Hydride Transfer for E. coli Thymidylate Synthase
Gurevic, Ilya; Islam, Zahidul; Świderek, Katarzyna; Trepka, Kai; Ghosh, Ananda K; Moliner, Vicent; Kohen, Amnon American Chemical Society (2018)Thymidylate synthase (TSase), an enzyme responsible for the de novo biosynthesis of 2′-deoxythymidine 5′-monophosphate (thymidylate, dTMP) necessary for DNA synthesis, has been a drug target for decades. TSase is a highly ...