Listar por autoría "ff7b48d1-5994-43a4-acc8-1eef94a1d02a"
Mostrando ítems 1-7 de 7
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Abacavir induces platelet-endothelium interactions by interfering with purinergic signalling: A step from inflammation to thrombosis
Álvarez, Ángeles; Rios-Navarro, Cesar; Blanch-Ruiz, Maria Amparo; Collado-Diaz, Victor; Andújar, Isabel; Martinez-Cuesta, Maria Angeles; Orden, Samuel; Esplugues Mota, Juan V. Elsevier (2017-05)The controversy connecting Abacavir (ABC) with cardiovascular disease has been fuelled by the lack of a credible mechanism of action. ABC shares structural similarities with endogenous purines, signalling molecules capable ... -
ER stress in human hepatic cells treated with Efavirenz: Mitochondria again
Apostolova, Nadezda; Gómez Sucerquia, Leysa J.; Alegre, Fernando; Funes, Haryes A.; Víctor, Víctor M.; Barrachina Sancho, María Dolores; Blas García, Ana; Esplugues Mota, Juan V. Elsevier (2013-10)Background & Aims ER stress is associated with a growing number of liver diseases, including drug-induced hepatotoxicity. The non-nucleoside analogue reverse transcriptase inhibitor Efavirenz, a cornerstone of the ... -
Heat Stress Induces Extended Plateau of Hsp70 Accumulation – A Possible Cytoprotection Mechanism in Hepatic Cells
Miova, Biljana; Dinevska-Kjovkarovska, Suzana; Esplugues Mota, Juan V.; Apostolova, Nadezda Wiley (2015-08-15)The relevance of heat preconditioning resides in its ability to protect cells from different kinds of injury by induction of heat shock proteins, a process in which the intensity of heat stress (HS) and duration of subsequent ... -
Involvement of nitric oxide in the mitochondrial action of efavirenz: a differential effect on neurons and glial cells
Apostolova, Nadezda; Funes, Haryes A.; Blas García, Ana; Alegre, Fernando; Polo, Míriam; Esplugues Mota, Juan V. Oxford University Press (2014-12)The anti-human immunodeficiency virus (HIV) drug efavirenz (EFV) alters mitochondrial function in cultured neurons and glial cells. Nitric oxide (NO) is a mediator of mitochondrial dysfunction associated with HIV central ... -
Mitochondrial (dys)function-a factor underlying the variability of EFV-induced hepatoxicity?
Polo, Míriam; Alegre, Fernando; Funes, Haryes A.; Blas García, Ana; Víctor, Víctor M.; Esplugues Mota, Juan V.; Apostolova, Nadezda Wiley (2015-01-08)Background and PurposeThe non-nucleoside analogue reverse transcriptase inhibitor efavirenz is associated with hepatic toxicity and metabolic disturbances. Although the mechanisms involved are not clear, recent evidence ... -
Neuronal Bioenergetics and Acute Mitochondrial Dysfunction: A Clue to Understanding the Central Nervous System Side Effects of Efavirenz
Funes, Haryes A.; Apostolova, Nadezda; Alegre, Fernando; Blas García, Ana; Álvarez, Ángeles; Martí Cabrera, Miguel; Esplugues Mota, Juan V. Oxford University Press (2014-05)Background. Neurological pathogenesis is associated with mitochondrial dysfunction and differences in neuronal/glial handling of oxygen and glucose. The main side effects attributed to efavirenz involve the CNS, but the ... -
The purine analogues abacavir and didanosine increase acetaminophen-induced hepatotoxicity by enhancing mitochondrial dysfunction
Blas García, Ana; Martí Rodrigo, Alberto; Víctor, Víctor M.; Polo, Míriam; Alegre, Fernando; Funes, Haryes A.; Apostolova, Nadezda; Esplugues Mota, Juan V. Oxford University Press (2016-01-07)Background NRTIs are essential components of HIV therapy with well-documented, long-term mitochondrial toxicity in hepatic cells, but whose acute effects on mitochondria are unclear. As acetaminophen-induced hepatotoxicity ...