• openAccess   Changes in myocardial iron content following administration of intravenous iron (Myocardial‐IRON): Study design 

      Miñana, Gema; Cardells, Ingrid; Palau, Patricia; Llàcer, Pau; Facila Rubio, Lorenzo; Almenar, Luis; López‐Lereu, Maria Pilar; Monmeneu, Jose V.; Amiguet, Martina; González, Jessika; Serrano, Alicia; Montagud, Vicente; López‐Vilella, Raquel; Valero, Ernesto; García-Blas, Sergio; Bodí, Vicent; De la Espriella, Rafael; Sanchis, Juan; Chorro, Francisco J.; Bayes-Genis, Antoni; Núñez, Julio; Myocardial‐IRON Investigators Wiley (2018)
      Treatment with intravenous ferric carboxymaltose (FCM) has been shown to improve symptoms, functional capacity, and quality of life in patients with heart failure and iron deficiency. However, the underlying mechanisms for ...
    • closedAccess   Chronotropic index and long-term outcomes in heart failure with preserved ejection fraction 

      Palau, Patricia; Domínguez Mafé, Eloy; Seller, Julia; Sastre, Clara; Sanchis, Juan; López, Laura; Bodí, Vicent; Llàcer, Pau; Miñana, Gema; De la Espriella, Rafael; Bayes-Genis, Antoni; Núñez, Julio Elsevier (2022)
      Introduction and objectives: Little is known about the usefulness of heart rate (HR) response to exercise for risk stratification in heart failure with preserved ejection fraction (HFpEF). Therefore, this study aimed ...
    • openAccess   Dapagliflozin and short-term changes on circulating antigen carbohydrate 125 in heart failure with reduced ejection fraction 

      Amiguet, Martina; Palau, Patricia; Domínguez Mafé, Eloy; Seller, Julia; GARCIA-PINILLA, JOSE MANUEL; De la Espriella, Rafael; Miñana, Gema; Valle, Alfonso; Sanchis, Juan; Górriz, José Luis; Bayes-Genis, Antoni; DAPA-VO2 Investigators, /; Núñez, Julio Nature Research (2023)
      Circulating antigen carbohydrate 125 (CA125) has emerged as a proxy of fluid overload in heart failure. This study aimed to evaluate the effect of dapagliflozin on short-term CA125 levels in patients with stable heart ...
    • closedAccess   Differential prognostic impact of type 2 diabetes mellitus in women and men with heart failure with preserved ejection fraction 

      Palau, Patricia; Bertomeu-González, Vicente; Sanchis, Juan; Soler Costa, Meritxell; De la Espriella, Rafael; Domínguez Mafé, Eloy; Santas, Enrique; Núñez, Eduardo; Chorro, Francisco J.; Miñana, Gema; Bayes-Genis, Antoni; Núñez, Julio Elsevier (2019)
      Introduction and objectives Type 2 diabetes mellitus (DM2) is a common comorbidity in patients with heart failure (HF) with preserved ejection fraction (HFpEF). Previous studies have shown that diabetic women are at ...
    • closedAccess   Early effects of empagliflozin on exercise tolerance in patients with heart failure: A pilot study. 

      Núñez, Julio; Palau, Patricia; Domínguez Mafé, Eloy; Mollar, Anna; Núñez, Eduardo; Ramón, José María; Miñana, Gema; Santas, Enrique; Facila Rubio, Lorenzo; Górriz, José Luis; Sanchis, Juan; Bayes-Genis, Antoni Wiley (2018-04-17)
      Background: Sodium-glucose linked transporter 2 inhibition recently emerged as a promising ther- apy for reducing the risk of heart failure (HF) in patients with type 2 diabetes mellitus (T2DM). However, there is a lack ...
    • openAccess   Effect of β-Blocker Withdrawal on Functional Capacity in Heart Failure and Preserved Ejection Fraction 

      Palau, Patricia; Seller, Julia; Domínguez Mafé, Eloy; Sastre, Clara; Ramón, Jose María; De la Espriella, Rafael; Santas, Enrique; Miñana, Gema; Bodí, Vicent; Sanchis, Juan; Valle, Alfonso; Chorro, F. Javier; Llácer, Pau; Bayes-Genis, Antoni; Núñez, Julio Elsevier (2021-11-15)
      BACKGROUND Chronotropic incompetence has shown to be associated with a decrease in exercise capacity in heart failure with preserved ejection fraction (HFpEF), yet b-blockers are commonly used in HFpEF despite the lack ...
    • closedAccess   Entrenamiento de la musculatura inspiratoria y la electroestimulación muscular funcional en el tratamiento de la insuficiencia cardiaca con función sistólica conservada: estudio TRAINING-HF 

      Palau, Patricia; Domínguez Mafé, Eloy; López, Laura; Ramón, José María; Heredia, Raquel; González, Jessika; Santas, Enrique; Bodí, Vicent; Miñana, Gema; Valero, Ernesto; Mollar, Anna; Bertomeu-González, Vicente; Chorro, Francisco J.; Sanchis, Juan; Lupón, Josep; Bayes-Genis, Antoni; Núñez, Julio Elsevier (2018)
      Introducción y objetivos No se dispone de tratamientos farmacológicos que demuestren reducir la morbimortalidad asociada en pacientes con insuficiencia cardiaca y función sistólica conservada (IC-FEc). El objetivo del ...
    • closedAccess   Inspiratory Muscle Function and Exercise Capacity in Patients with Heart Failure with Preserved Ejection Fraction 

      Palau, Patricia; Domínguez Mafé, Eloy; Núñez, Eduardo; Ramón, José María; López, Laura; Melero, Joana; Bellver, Alejandro; Chorro, Francisco J.; Bodí, Vicent; Bayes-Genis, Antoni; Sanchis, Juan; Núñez, Julio Elsevier (2017-06)
      Background Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome characterized by impaired exercise capacity resulting from dyspnea and fatigue. The pathophysiological mechanisms underlying the ...
    • closedAccess   Iron deficiency and short-term adverse events in patients with decompensated heart failure 

      Palau, Patricia; Llàcer, Pau; Domínguez Mafé, Eloy; Tormo, Juan Pablo; Zakarne, Rim; Mollar, Anna; Martínez, Ana; Miñana, Gema; Santas, Enrique; Almenar-Bonet, Luis; Fácila, Lorenzo; De la Espriella, Rafael; Núñez, Eduardo; Manzano, Luis; Bayes-Genis, Antoni; Núñez, Julio Springer (2021-03-15)
      Background: For patients with heart failure (HF), iron deficiency (ID) is a common therapeutic target. However, little is known about the utility of transferrin saturation (TSAT) or serum ferritin for risk stratification ...
    • openAccess   Rehospitalization burden and morbidity risk in patients with heart failure with mid-range ejection fraction 

      Santas, Enrique; De la Espriella, Rafael; Palau, Patricia; Miñana, Gema; Amiguet Comins, Martina; Sanchis, Juan; Lupón, Josep; Bayes-Genis, Antoni; Chorro, Francisco J.; Núñez, Julio Wiley (2020-03-25)
      Aims Heart failure with mid-range ejection fraction (HFmrEF) has been proposed as a distinct HF phenotype, but whether patients on this category fare worse, similarly, or better than those with HF with reduced EF (HFrEF) ...
    • openAccess   Right Ventricular Dysfunction Staging System for Mortality Risk Stratifiction in Heart Failure with Preserved Ejection Fraction 

      Santas, Enrique; De la Espriella, Rafael; Chorro, Francisco J.; Palau, Patricia; Miñana, Gema; Heredia, Raquel; Amiguet Comins, Martina; Merenciano Gonzalez, Hector; Sanchis, Juan; Lupón, Josep; Bayes-Genis, Antoni; Núñez, Julio MDPI (2020-03-18)
      Right ventricular dysfunction (RVD) parameters are increasingly important features in heart failure with preserved ejection fraction (HFpEF). We sought to evaluate the prognostic impact of a progressive RVD staging system ...
    • closedAccess   Short-term Changes in Hemoglobin and Changes in Functional Status, Quality of Life and Natriuretic Peptides After Initiation of Dapagliflozin in Heart Failure With Reduced Ejection Fraction 

      Lorenzo, Miguel; Miñana, Gema; Palau, Patricia; Amiguet, Martina; Seller, Julia; García Pinilla, José Manuel; Villar, Sandra; De la Espriella, Rafael; Núñez, Eduardo; Górriz, José Luis; Valle, Alfonso; Bodí, Vicent; Sanchis, Juan; Bayes-Genis, Antoni; Núñez, Julio; DAPA-VO2 Investigators Elsevier (2023-05)
      Background: We aimed to evaluate the effect of dapagliflozin on short-term changes in hemoglobin in patients with stable heart failure with reduced ejection fraction (HFrEF) and whether these changes mediated the effect ...
    • closedAccess   Short-term effects of dapagliflozin on maximal functional capacity in heart failure with reduced ejection fraction (DAPA-VO2): a randomized clinical trial 

      Palau, Patricia; Amiguet Comins, Martina; Domínguez Mafé, Eloy; Sastre, Clara; Mollar, Anna; Seller, Julia; GARCIA-PINILLA, JOSE MANUEL; Larumbe, Ainoha; Valle, Alfonso; Gómez Doblas, Juan José; De la Espriella, Rafael; Miñana, Gema; Robles Mezcua, Ainhoa; Santas, Enrique; Bodí, Vicent; Sanchis, Juan; Pascual-Figal, Domingo A.; Gorriz, Jose Luis; Bayes-Genis, Antoni; Núñez, Julio Wiley (2022-05-23)
      Aims This study aimed to evaluate the effect of dapagliflozin on 1 and 3-month maximal functional capacity in patients with stable heart failure with reduced ejection fraction (HFrEF). Methods and results In this ...
    • closedAccess   Usefulness of Right Ventricular to Pulmonary Circulation Coupling as an Indicator of Risk for Recurrent Admissions in Heart Failure With Preserved Ejection Fraction 

      Santas, Enrique; Palau, Patricia; Guazzi, Marco; De la Espriella, Rafael; Miñana, Gema; Sanchis, Juan; Bayes-Genis, Antoni; Lupón, Josep; Chorro, Francisco J.; Núñez, Julio Elsevier (2019)
      In recent years, the study of right ventricular (RV) to pulmonary circulation (PC) coupling in heart failure with preserved ejection fraction (HFpEF) has been a matter of special interest. Tricuspid annular plane systolic ...