Listar por autoría "67b99dbc-066a-4875-b7e0-ab8e98e10067"
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Acquisition and reconditioning of ethanol-induced conditioned place preference in mice is blocked by the H2O2 scavenger alpha lipoic acid
Ledesma Llorente, Juan Carlos; González Aragón, Carlos Manuel Springer (2012)Rationale Hydrogen peroxide (H2 O2) is the co-substrate used by catalase to metabolize ethanol to acetaldehyde in the brain. This centrally formed acetaldehyde has been involved in several ethanol-related behaviors. ... -
Alpha-lipoic acid, a scavenging agent for H2O2, reduces ethanol-stimulated locomotion in mice
Ledesma Llorente, Juan Carlos; González Aragón, Carlos Manuel Springer-Verlag (2011-07-19)Rationale The main system of central ethanol oxidation is mediated by the enzyme catalase. By reacting with H2O2, brain catalase forms compound I (the catalase–H2O2 system), which is able to oxidize ethanol to acetaldehyde ... -
In Vivo Study of Ethanol-Activated Brain Protein Kinase A: Manipulations of Ca2+ Distribution and Flux
Baliño, Pablo; Ledesma Llorente, Juan Carlos; González Aragón, Carlos Manuel Wiley (2014-03)Background The cAMP-dependent protein kinase (PKA) signaling transduction pathway has been shown to play an important role in the modulation of several ethanol (EtOH)-induced behavioral actions. In vivo, short-term ... -
Induction of brain cytochrome P450 2E1 boosts the locomotor-stimulating effects of ethanol in mice
Ledesma Llorente, Juan Carlos; MIQUEL, MARTA; Pascual, María; Guerri, Consuelo; González Aragón, Carlos Manuel Elsevier (2014)In the central nervous system ethanol (EtOH) is metabolized into acetaldehyde by different enzymes. Brain catalase accounts for 60% of the total production of EtOH-derived acetaldehyde, whereas cerebral cytochrome P450 2E1 ... -
Modulation of ethanol-induced conditioned place preference in mice by 3-amino-1,2,4-triazole and D-penicillamine depends on ethanol dose and number of conditioning trials
Ledesma Llorente, Juan Carlos; Font Hurtado, Laura; Baliño, Pablo; González Aragón, Carlos Manuel Springer (2013)Previous studies have shown that both 3-amino-1,2,4-triazole (AT), which inhibits metabolism of ethanol (EtOH) to acetaldehyde by inhibiting catalase, and D-penicillamine (D-P), an acetaldehyde-sequestering agent, modulate ... -
Reduction in Central H2O2 Levels Prevents Voluntary Ethanol Intake in Mice: A Role for the Brain Catalase- H2O2 System in Alcohol Binge Drinking
Ledesma Llorente, Juan Carlos; Baliño, Pablo; González Aragón, Carlos Manuel Wiley (2014-01)Background: Hydrogen peroxide (H2O2) is the cosubstrate used by the enzyme catalase to form Compound I (the catalase-H2O2 system), which is the major pathway for the conversion of ethanol (EtOH) into acetaldehyde in the ... -
Role of CA2+/calmodulin on ethanol neurobehavioral effects
González Aragón, Carlos Manuel; Ledesma Llorente, Juan Carlos; Baliño, Pablo Springer (2014-05)Rationale. The cAMP-dependent protein kinase A (PKA) signaling transduction pathway has been shown to play an important role in the modulation of several ethanol-induced behaviors. Different studies have demonstrated ... -
Role of phosphodiesterase-4 on ethanol elicited locomotion and narcosis
Baliño, Pablo; Ledesma Llorente, Juan Carlos; González Aragón, Carlos Manuel Elsevier (2016)The cAMP signaling pathway has emerged as an important modulator of the pharmacological effects of ethanol. In this respect, the cAMP-dependent protein kinase has been shown to play an important role in the modulation of ... -
The H2O2 scavenger ebselen decreases ethanol-induced locomotor stimulation in mice
Ledesma Llorente, Juan Carlos; González Aragón, Carlos Manuel; Font Hurtado, Laura Elsevier (2012)Background In the brain, the enzyme catalase by reacting with H2O2 forms Compound I (catalase–H2O2 system), which is the main system of central ethanol metabolism to acetaldehyde. Previous research has demonstrated that ... -
The MAO-A inhibitor clorgyline reduces ethanol-induced locomotion and its volitional intake in mice
Ledesma Llorente, Juan Carlos; Escrig, Miguel A.; Pastor Medall, Raúl; González Aragón, Carlos Manuel Elsevier (2014)Hydrogen peroxide is the co-substrate used by the enzyme catalase to form Compound I (the catalase–H2O2 system), which is the major pathway for the conversion of ethanol (EtOH) into acetaldehyde in the brain. This acetaldehyde ...