Listar por autoría "3ddd9992-0b80-405c-9d7f-9357ba0212e7"
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Ceria nanoparticles with rhodamine B as a powerful theranostic agent against intracellular oxidative stress
Apostolova, Nadezda; Rovira Llopis, Susana; Baldoví, Herme G.; Navalón, Sergio; Asiri, Abdullah M.; Víctor, Víctor M.; García, Hermenegildo; Herance, Jose Raul Royal Society of Chemistry (2015-09)Ceria nanoparticles with rhodamine B groups covalently attached on their surface (RhB-CeNPs) were successfully prepared to simultaneously exhibit antioxidant activity and the ability to detect oxidant species. In order to ... -
Efavirenz and the CNS: what we already know and questions that need to be answered
Apostolova, Nadezda; Funes, Haryes A.; Blas García, Ana; Galindo, Maria J.; Álvarez, Ángeles; Esplugues, Juan V. Oxford University Press (2015-07)The NNRTI efavirenz has long been one of the most frequently employed antiretroviral drugs in the multidrug regimens used to treat HIV infection, in accordance with its well-demonstrated antiretroviral efficacy and ... -
ER stress in human hepatic cells treated with Efavirenz: Mitochondria again
Apostolova, Nadezda; Gómez Sucerquia, Leysa J.; Alegre, Fernando; Funes, Haryes A.; Víctor, Víctor M.; Barrachina Sancho, María Dolores; Blas García, Ana; Esplugues Mota, Juan V. Elsevier (2013-10)Background & Aims ER stress is associated with a growing number of liver diseases, including drug-induced hepatotoxicity. The non-nucleoside analogue reverse transcriptase inhibitor Efavirenz, a cornerstone of the ... -
Heat Stress Induces Extended Plateau of Hsp70 Accumulation – A Possible Cytoprotection Mechanism in Hepatic Cells
Miova, Biljana; Dinevska-Kjovkarovska, Suzana; Esplugues Mota, Juan V.; Apostolova, Nadezda Wiley (2015-08-15)The relevance of heat preconditioning resides in its ability to protect cells from different kinds of injury by induction of heat shock proteins, a process in which the intensity of heat stress (HS) and duration of subsequent ... -
Involvement of nitric oxide in the mitochondrial action of efavirenz: a differential effect on neurons and glial cells
Apostolova, Nadezda; Funes, Haryes A.; Blas García, Ana; Alegre, Fernando; Polo, Míriam; Esplugues Mota, Juan V. Oxford University Press (2014-12)The anti-human immunodeficiency virus (HIV) drug efavirenz (EFV) alters mitochondrial function in cultured neurons and glial cells. Nitric oxide (NO) is a mediator of mitochondrial dysfunction associated with HIV central ... -
Is Glycemic Control Modulating Endoplasmic Reticulum Stress in Leukocytes of Type 2 Diabetic Patients?
Rovira Llopis, Susana; Bañuls, Celia; Apostolova, Nadezda; Morillas, Carlos; Hernández Mijares, Antonio; Rocha, Milagros; Víctor, Víctor M. Mary Ann Liebert Inc. (2014-10-06)Oxidative and endoplasmic reticulum (ER) stress is related to type 2 diabetes (T2D), but the influence of glycemic control on these parameters and its relationship with leukocyte-endothelial interactions is not known. In ... -
Mitochondrial (dys)function-a factor underlying the variability of EFV-induced hepatoxicity?
Polo, Míriam; Alegre, Fernando; Funes, Haryes A.; Blas García, Ana; Víctor, Víctor M.; Esplugues Mota, Juan V.; Apostolova, Nadezda Wiley (2015-01-08)Background and PurposeThe non-nucleoside analogue reverse transcriptase inhibitor efavirenz is associated with hepatic toxicity and metabolic disturbances. Although the mechanisms involved are not clear, recent evidence ... -
Molecular Strategies for Targeting Antioxidants to Mitochondria: Therapeutic Implications
Apostolova, Nadezda; Víctor, Víctor M. Mary Ann Liebert (2015-03-10)Mitochondrial function and specifically its implication in cellular redox/oxidative balance is fundamental in controlling the life and death of cells, and has been implicated in a wide range of human pathologies. In this ... -
Neuronal Bioenergetics and Acute Mitochondrial Dysfunction: A Clue to Understanding the Central Nervous System Side Effects of Efavirenz
Funes, Haryes A.; Apostolova, Nadezda; Alegre, Fernando; Blas García, Ana; Álvarez, Ángeles; Martí Cabrera, Miguel; Esplugues Mota, Juan V. Oxford University Press (2014-05)Background. Neurological pathogenesis is associated with mitochondrial dysfunction and differences in neuronal/glial handling of oxygen and glucose. The main side effects attributed to efavirenz involve the CNS, but the ... -
Perspectives and Potential Applications of Mitochondria-Targeted Antioxidants in Cardiometabolic Diseases and Type 2 Diabetes
Rocha, Milagros; Apostolova, Nadezda; Herance, Jose Raul; Rovira Llopis, Susana; Hernández Mijares, Antonio; Víctor, Víctor M. John Wiley & Sons (2013)There is abundant evidence to suggest that mitochondrial dysfunction is a main cause of insulin resistance and related cardiometabolic comorbidities. On the other hand, insulin resistance is one of the main characteristics ... -
Self-assembled multivalent (SAMul) ligand systems with enhanced stability in the presence of human serum
Tena Solsona, Marta; Marson, Domenico; Rodrigo, Ana C.; Bromfield, Stephen M.; Escuder, Beatriu; Miravet, Juan; Apostolova, Nadezda; Laurini, Erik; Pricl, Sabrina Royal Society of Chemistry (2019)Self-assembled cationic micelles are an attractive platform for binding biologically-relevant polyanions such as heparin. This has potential applications in coagulation control, where a synthetic heparin rescue agent could ... -
Synthesis, spectroscopic studies and biological evaluation of acridine derivatives: The role of aggregation on the photodynamic efficiency
Felip-León, Carles; Martínez Arroyo, Olga; Diaz-Oltra, Santiago; Miravet, Juan; Apostolova, Nadezda; Galindo, Francisco Elsevier (2018-03-01)Two new photoactive compounds (1 and 2) derived from the 9-amidoacridine chromophore have been synthesized and fully characterized. Their abilities to produce singlet oxygen upon irradiation have been compared. The synthesized ... -
The purine analogues abacavir and didanosine increase acetaminophen-induced hepatotoxicity by enhancing mitochondrial dysfunction
Blas García, Ana; Martí Rodrigo, Alberto; Víctor, Víctor M.; Polo, Míriam; Alegre, Fernando; Funes, Haryes A.; Apostolova, Nadezda; Esplugues Mota, Juan V. Oxford University Press (2016-01-07)Background NRTIs are essential components of HIV therapy with well-documented, long-term mitochondrial toxicity in hepatic cells, but whose acute effects on mitochondria are unclear. As acetaminophen-induced hepatotoxicity ... -
Using exomarkers to assess mitochondrial reactive species in vivo
Logan, Angela; Cochemé, Helena M.; Boon Li Pun, Pamela; Apostolova, Nadezda; Smith, Robin A. J.; Larsen, Lesley; Larsen, David S.; James, Andrew M.; Fearnley, Ian M.; Rogatti, Sebastian; Prime, Tracy A.; Finichiu, Peter G.; Dare, Anna; Chouchani, Edward T.; Pell, Victoria R.; Methner, Carmen; Quin, Caroline; McQuaker, Stephen J.; Krieg, Thomas; Hartley, Richard C.; Murphy, Michael P. Elsevier (2014-02)Background The ability to measure the concentrations of small damaging and signalling molecules such as reactive oxygen species (ROS) in vivo is essential to understanding their biological roles. While a range of methods ...