Listar por autoría "0bd09ebd-a74e-418b-a095-e5459cc7ce97"

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    • openAccess   Aryl azoles based scaffolds for disrupting tumor microenvironment 

      Pla López, Alberto; Martinez-Colomina, Paula; Cañada-García, Laura; Fuertes-Monge, Laura; Orellana-Palacios, Jose C.; Valderrama-Martínez, Alejandro; Pérez Sosa, Marikena; Carda, Miguel; Falomir, Eva Elsevier (2023-11-15)
      Thirty-nine aryl azoles, thirteen triazoles and twenty-seven tetrazoles, have been synthetized and biologically evaluated to determine their activity as tumor microenvironment disruptors. Antiproliferative studies have ...

    • closedAccess   In search of new anticancer compounds with immunomodulatory action 

      Pla López, Alberto Universitat Jaume I (2018-07)
      The main idea of the research line that is being studying in the group is focused on the design and synthesis of dual inhibitors of both biological targets explained in the introduction: c-Myc and PD-L1. According to the ...

    • closedAccess   Síntesis de diaril-triazoles y estudio de su actividad inmunomoduladora y multidiana 

      Pla López, Alberto Universitat Jaume I (2019-07)
      El grupo en el cual se ha desarrollado este trabajo presenta diversas líneas de investigación, entre las que destacan la búsqueda, diseño y síntesis de moléculas que puedan actuar al mismo tiempo sobre diversas ...

    • openAccess   Synthesis and Biological Evaluation of Small Molecules as Potential Anticancer Multitarget Agents 

      Pla López, Alberto; Castillo, Raquel; Cejudo Marín, Rocío; García Pedrero, Olaya; Bakir Laso, Mariam; Falomir, Eva; Miguel Carda MDPI (2022-06-24)
      Twenty-six triazole-based derivatives were designed for targeting both PD-L1 (programmed death receptor ligand 1) and VEGFR-2 (vascular endothelial growth factor receptor 2). These compounds were synthetized and biologically ...