Turning on and off the cerebellum in drug-induced memory
Metadata
Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/29747
comunitat-uji-handle3:10234/177892
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TESISMetadata
Title
Turning on and off the cerebellum in drug-induced memoryAuthor (s)
Director
MIQUEL, MARTADoctoral Studies
Programa de Doctorat en Ciències Biomèdiques i SalutResponsible entity
Universitat Jaume I. Escola de DoctoratDate of defense
2024-02-27Publisher
Universitat Jaume ISubject
Keywords
Pages
156 p.Abstract
This thesis examines the role of the cerebellum in drug-induced memories and its connection to the addiction circuit. First, we identify changes in neuronal activity in the cerebellar vermis during the expression of ... [+]
This thesis examines the role of the cerebellum in drug-induced memories and its connection to the addiction circuit. First, we identify changes in neuronal activity in the cerebellar vermis during the expression of cocaine-associated memories, highlighting differences in the granular layer of the VIII lobe between rats with and without a preference for cocaine-related stimuli. Furthermore, using DREADDs, we reveal that the activation and inhibition of interneurons in the VIII lobe affect preference for cocaine-associated stimuli. On the other hand, we propose a theoretical model and show that inactivation of the DCN prevents the facilitating effect of a lesion in cocaine-conditioned preference. Finally, we observe the regulation of the cerebellum on IL activity through the VTA. In summary, the thesis advances understanding of the cerebellum in addiction, offering therapeutic possibilities to address the behavioral alterations associated with addiction. [-]
Rights
L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-sa/4.0/
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess