Functional interactions of Infralimbic-Cerebellum pathways in cocaine-induced preference memory
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/29747
comunitat-uji-handle3:10234/177892
comunitat-uji-handle4:
TESISMetadatos
Título
Functional interactions of Infralimbic-Cerebellum pathways in cocaine-induced preference memoryAutoría
Director/a
MIQUEL, MARTA; Khodakhah, KamranPrograma de Doctorado
Programa de Doctorat en Ciències Biomèdiques i SalutÓrgano responsable
Universitat Jaume I. Escola de DoctoratFecha de defensa
2023-07-20Descripción
Doctorat internacional
Editor
Universitat Jaume IPalabras clave
Área de conocimiento
Páginas
287 p.Resumen
The present thesis investigates the cerebellum-IL interactions in drug-induced memories and their anatomical pathways. To do so, we 1) assessed activity and perineuronal nets (PNNs) expression in the posterior cerebellum ... [+]
The present thesis investigates the cerebellum-IL interactions in drug-induced memories and their anatomical pathways. To do so, we 1) assessed activity and perineuronal nets (PNNs) expression in the posterior cerebellum of IL-inactivated rats, 2) digested PNNs in LVIII at different time points of the learning process, and 3) created an anatomical map of the ascending and descending cerebellum-IL reciprocal pathways using tracing agents. First, IL inactivation promoted cocaine-induced memory acquisition and upregulated cFos and vGluT2 activity around neurogranin+ Golgi interneurons and PNN expression in the posterior cerebellum. Second, LVIII PNNs enzymatic digestion disrupted short-term cocaine memory and facilitated reinstatement of cocaine-induced memory probably by preventing the consolidation of extinction. Third, our anatomical maps show that LVIII via the interposed DCN might contact VTA and then contact IL, and IL might send projections to both interposed DCN and inferior olive and these areas that reach LVIII. [-]
Derechos de acceso
L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-sa/4.0/
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess