Electrophysiological characterization of membrane permeability: from protein channels to nanoparticles
Metadades
Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/29747
comunitat-uji-handle3:10234/162741
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TESISMetadades
Títol
Electrophysiological characterization of membrane permeability: from protein channels to nanoparticlesAutoria
Director/a
Alcaraz, Antonio; Queralt-Martín, MaríaPrograma de Doctorat
Programa de Doctorat en CiènciesÒrgan responsable
Universitat Jaume I. Escola de DoctoratData de defensa
2022-12-14Descripció
Doctorat internacional
Editor
Universitat Jaume IParaules clau
Àrea de coneixement
Pàgines
198 p.Resum
Cell membrane permeability is modulated by complex dynamical structures created by objects interacting with the lipid bilayer. Paying attention to the kinetics of ion transport in response to different bioelectrochemical ... [+]
Cell membrane permeability is modulated by complex dynamical structures created by objects interacting with the lipid bilayer. Paying attention to the kinetics of ion transport in response to different bioelectrochemical signals, we use planar bilayer electrophysiology to provide a perspective on membrane permeabilization mechanisms that goes from order to disorder as regards to the pore conformational dynamics. We first study stable channels shaped by large transmembrane proteins like OmpF. Next, we provide insights on lipid-peptide interactions leading to the formation of pores by Dynorphin A neuropeptides. Finally, we describe selective ion channels induced by large complex objects like plastic nanoparticles while the global bilayer integrity is maintained. Overall, the particular balance between hydrophobic and hydrophilic interactions is revealed in different ways in each system, either modulating the open and closed states of channels formed by membrane proteins or in the surface functionalization of nanoparticles that rules their interactions with membranes. [-]
Drets d'accés
L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-sa/4.0/
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess