Neural efficiency of a specific cognitive training in working memory in multiple sclerosis patients
Metadata
Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/29747
comunitat-uji-handle3:10234/162756
comunitat-uji-handle4:
TESISMetadata
Title
Neural efficiency of a specific cognitive training in working memory in multiple sclerosis patientsAuthor (s)
Director
Forn Frías, Cristina; Ávila Rivera, CésarDoctoral Studies
Programa de Doctorat en PsicologiaResponsible entity
Universitat Jaume I. Escola de DoctoratDate of defense
2021-12-13Description
Publisher
Universitat Jaume ISubject
Keywords
Pages
148 p.;Abstract
Multiple sclerosis is an autoimmune degenerative disease that produces cognitive impairment secondary to white and gray matter disruption of the central nervous system. The main objectives of this doctoral thesis were: ... [+]
Multiple sclerosis is an autoimmune degenerative disease that produces cognitive impairment secondary to white and gray matter disruption of the central nervous system. The main objectives of this doctoral thesis were: First, to study spontaneous brain neuroplasticity processes associated with white matter lesions. Second, to study neuroplasticity processes induced after intensive working memory training. Regarding spontaneous neuroplasticity results, it was observed that white matter lesions located in the internal capsule are predominant in MS patients and cause functional connectivity changes that correlate negatively with cognitive performance. On the other hand, induced neuroplasticity results showed that a specific training in working memory produces similar neuroplasticity in patients as in healthy subjects. These changes in brain plasticity are also associated with cognitive performance improvement. These results can be interpreted as an increase in cognitive efficiency. [-]
Rights
L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-sa/4.0/
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess