Neural efficiency of a specific cognitive training in working memory in multiple sclerosis patients
Metadades
Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/29747
comunitat-uji-handle3:10234/162756
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TESISMetadades
Títol
Neural efficiency of a specific cognitive training in working memory in multiple sclerosis patientsAutoria
Director/a
Forn Frías, Cristina; Ávila Rivera, CésarPrograma de Doctorat
Programa de Doctorat en PsicologiaÒrgan responsable
Universitat Jaume I. Escola de DoctoratData de defensa
2021-12-13Descripció
Editor
Universitat Jaume IParaules clau
Àrea de coneixement
Pàgines
148 p.;Resum
Multiple sclerosis is an autoimmune degenerative disease that produces cognitive impairment secondary to white and gray matter disruption of the central nervous system. The main objectives of this doctoral thesis were: ... [+]
Multiple sclerosis is an autoimmune degenerative disease that produces cognitive impairment secondary to white and gray matter disruption of the central nervous system. The main objectives of this doctoral thesis were: First, to study spontaneous brain neuroplasticity processes associated with white matter lesions. Second, to study neuroplasticity processes induced after intensive working memory training. Regarding spontaneous neuroplasticity results, it was observed that white matter lesions located in the internal capsule are predominant in MS patients and cause functional connectivity changes that correlate negatively with cognitive performance. On the other hand, induced neuroplasticity results showed that a specific training in working memory produces similar neuroplasticity in patients as in healthy subjects. These changes in brain plasticity are also associated with cognitive performance improvement. These results can be interpreted as an increase in cognitive efficiency. [-]
Drets d'accés
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info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess