GC-MS/MS multi-residue method for the determination of organochlorine pesticides, polychlorinated biphenyls and polybrominated diphenyl ethers in human breast tissues
Impacte
![Google Scholar](/xmlui/themes/Mirage2/images/uji/logo_google.png)
![Microsoft Academico](/xmlui/themes/Mirage2/images/uji/logo_microsoft.png)
Metadades
Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7013
comunitat-uji-handle3:10234/8638
comunitat-uji-handle4:
INVESTIGACIONAquest recurs és restringit
http://dx.doi.org/10.1002/jssc.200800737 |
Metadades
Títol
GC-MS/MS multi-residue method for the determination of organochlorine pesticides, polychlorinated biphenyls and polybrominated diphenyl ethers in human breast tissuesData de publicació
2009Editor
WileyISSN
1615-9314Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://onlinelibrary.wiley.com/doi/10.1002/jssc.200800737/fullVersió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
In this work, a multiresidue method for the quantification and confirmation of around 30 organohalogenated compounds in human breast tissue samples has been developed. Analytes tested included organochlorine (OC) ... [+]
In this work, a multiresidue method for the quantification and confirmation of around 30 organohalogenated compounds in human breast tissue samples has been developed. Analytes tested included organochlorine (OC) (pesticides and polychlorinated biphenyls) and organobromine (OBr) (polybrominated diphenyl ether) compounds. The approach is based on a simple extraction with hexane, followed by a SPE clean-up using silica cartridges and final measurement by GC coupled to triple quadrupole MS. Analyses were performed in both ionizations, electron impact (EI) (selected reaction monitoring (SRM) mode) and negative chemical ionization (NCI) (selected ion recording (SIR) mode). Three isotopically labeled standards were added before extraction and used as surrogates: HCB-13C6, lindane-D6 and p,p′-DDE-D8. The method was validated in terms of accuracy, precision, LOQ and LOD and confirmation reliability, using breast tissue spiked at three concentration levels in the range 1–100 ng/g for OC compounds and at two levels 0.1 and 10 ng/g for OBr compounds (0.5 and 50 ng/g for BDE 209). The usefulness of the developed method was tested by the analysis of real human samples, giving as a result the detection of several OC and OBr compounds in different samples analyzed. The acquisition of at least two SRM transitions (in EI) or ions (in NCI) per analyte allowed positive findings to be confirmed by accomplishment of ion ratios between the quantification and the confirmation transitions or ions. [-]
Publicat a
Journal of Separation Science, 32, 12, p. 2090–2102Drets d'accés
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
Apareix a les col.leccions
- QFA_Articles [825]