Memantine prevents reference and working memory impairment caused by sleep deprivation in both young and aged Octodon degus
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Scholar |
Otros documentos de la autoría: Herrero Ezquerro, María Trinidad; Tarragon Cros, Ernesto; López, Dolores; Estrada, Cristina; González Cuello, Ana; Ros Gómez, Carmen María; Lamberty, Yves; Pifferi, Fabien; Cella, Massimo; Canovi, Mara; Guiso, Giovanna; Gobbi, Marco; Fernández Villalba, Emiliano; Blin, Olivier; Bordet, Regis; Richardson, Jill C.
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http://dx.doi.org/10.1016/j.neuropharm.2014.05.023 |
Metadatos
Título
Memantine prevents reference and working memory impairment caused by sleep deprivation in both young and aged Octodon degusAutoría
Fecha de publicación
2014-10Editor
ElsevierISSN
0028-3908Cita bibliográfica
TARRAGON, Ernesto, et al. Memantine prevents reference and working memory impairment caused by sleep deprivation in both young and aged Octodon degus. Neuropharmacology, 2014, vol. 85, pp 206-214Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.sciencedirect.com/science/article/pii/S0028390814001907Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Memory loss is one of the key features of cognitive impairment in either aging, Mild Cognitive Impairment (MCI) or dementia. Pharmacological treatments for memory loss are today focused on addressing symptomatology. ... [+]
Memory loss is one of the key features of cognitive impairment in either aging, Mild Cognitive Impairment (MCI) or dementia. Pharmacological treatments for memory loss are today focused on addressing symptomatology. One of these approved compounds is memantine, a partial NMDA receptor antagonist that has proved its beneficial effects in cognition. The Octodon degus (O. degus) has been recently proposed as a potential model relevant for neurodegenerative diseases. However, there are no previous studies investigating the effect of pharmacological treatments for age-related cognitive impairment in this rodent. In this work we aimed to evaluate the effect of memantine on sleep deprivation (SD)-induced memory impairment in young and old O. degus. Young and old animals were trained in different behavioral paradigms validated for memory evaluation, and randomly assigned to a control (CTL, n = 14) or an SD (n = 14) condition, and treated with vehicle or memantine (10-mg/Kg i.p.) before the SD started. We demonstrate that SD impairs memory in both young and old animals, although the effect in the old group was significantly more severe (P < 0.05). Memantine pretreatment was able to prevent the cognitive impairment caused by SD in both age groups, while it had no negative effect on CTL animals. The positive effect of memantine in counteracting the negative effect of SD on the retrieval process even in the aged O. degus further supports the translational potential of both the challenge and the species, and will enable a better understanding of the behavioral features of memantine effects, especially related with reference and working memories. [-]
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Neuropharmacology (2014) vol. 85Derechos de acceso
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- MED_Articles [667]