Piecing together the puzzle of acetaldehyde as a neuroactive agent
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Scholar |
Otros documentos de la autoría: Correa, Merce; Salamone, John; Segovia, Kristen N.; Pardo Andrés, Marta; Longoni, Rosanna; Spina, Liliana; PEANA, Alessandra Tiziana; Vinci, Stefania; Acquas, Elio
Metadatos
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http://dx.doi.org/10.1016/j.neubiorev.2011.07.009 |
Metadatos
Título
Piecing together the puzzle of acetaldehyde as a neuroactive agentAutoría
Fecha de publicación
2012-01Editor
ElsevierISSN
0149-7634Cita bibliográfica
Neuroscience & Biobehavioral Reviews, 36 , 1, p. 404-430Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.sciencedirect.com/science/article/pii/S0149763411001448Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Mainly known for its more famous parent compound, ethanol, acetaldehyde was first studied in the 1940s, but then research interest in this compound waned. However, in the last two decades, research on acetaldehyde has ... [+]
Mainly known for its more famous parent compound, ethanol, acetaldehyde was first studied in the 1940s, but then research interest in this compound waned. However, in the last two decades, research on acetaldehyde has seen a revitalized and uninterrupted interest. Acetaldehyde, per se, and as a product of ethanol metabolism, is responsible for many pharmacological effects which are not clearly distinguishable from those of its parent compound, ethanol. Consequently, the most recent advances in acetaldehyde's psychopharmacology have been inspired by the experimental approach to test the hypothesis that some of the effects of ethanol are mediated by acetaldehyde and, in this regard, the characterization of metabolic pathways for ethanol and the localization within discrete brain regions of these effects have revitalized the interest on the role of acetaldehyde in ethanol's central effects. Here we present and discuss a wealth of experimental evidence that converges to suggest that acetaldehyde is an intrinsically active compound, is metabolically generated in the brain and, finally, mediates many of the psychopharmacological properties of ethanol. [-]
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© 2011 Elsevier Ltd. All rights reserved
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