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Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys
dc.contributor.author | Heman, Paola | |
dc.contributor.author | Barcia, Carlos | |
dc.contributor.author | Gómez, Aurora | |
dc.contributor.author | Ros Gómez, Carmen María | |
dc.contributor.author | Ros Bernal, Francisco | |
dc.contributor.author | Yuste Jiménez, José Enrique | |
dc.contributor.author | De Pablos, Vicente | |
dc.contributor.author | Fernández Villalba, Emiliano | |
dc.contributor.author | Toledo-Cárdenas, María Rebeca | |
dc.contributor.author | Herrero Ezquerro, María Trinidad | |
dc.date.accessioned | 2013-09-13T14:31:50Z | |
dc.date.available | 2013-09-13T14:31:50Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Histol Histopathol (2012) 27: 89-94 | ca_CA |
dc.identifier.issn | 0213-3911 | |
dc.identifier.issn | 1699-5848 | |
dc.identifier.uri | http://hdl.handle.net/10234/72926 | |
dc.description.abstract | In the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic Parkinsonism. In our study, we observed a persistent activation of Purkinje cells in the cerebellum of chronic parkinsonian macaques, characterized by the expression of c-Fos, which correlated with dopaminergic degeneration. These results are compatible with the results observed in fMRI in Parkinson’s disease patients, and may contribute to the understanding of additional alterations in the brain circuitry in Parkinsonism. | ca_CA |
dc.format.extent | 6 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Universidad de Murcia | ca_CA |
dc.relation.isPartOf | Histology and Histopathology, 2012, Num. 27 | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/CNE/1.0/ | * |
dc.subject | Parkinson’s disease | ca_CA |
dc.subject | Cerebellum | ca_CA |
dc.subject | MPTP | ca_CA |
dc.subject | Purkinje cells | ca_CA |
dc.subject | c-Fos | ca_CA |
dc.title | Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | http://www.hh.um.es/2012/HH_27_1_2012.htm | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion |
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