Buscar
Three-Step Telescoped Synthesis of Monosubstituted Vicinal Diamines from Aldehydes
(2019)
Aldehydes are easily transformed into vicinal diamines and piperazines through a one-pot procedure including a Darzens reaction and treatment with an amine or diamine and then with a reducing agent. Additionally, quinoxalines ...
Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3′-aminocombretastatin A-4
(Elsevier, 2019-01-15)
Twenty-six compounds derived from 3′-aminocombretastatin A-4 (AmCA-4) containing a urea fragment mimicking the structure of Sorafenib, have been synthesized and evaluated as antiangiogenic compounds. Antiproliferative ...
Rational design of a supramolecular gel based on a Zn(II)–salophen bis-dipeptide derivative
(Royal Society of Chemistry, 2016)
We report the rational design and synthesis of a supramolecular gelator based on a Zn(II)–salophen derivative functionalized with L-valine residues. This compound is able to gelate acetonitrile by self-assembly into helical ...
Convergent, stereoselective syntheses of the glycosidase inhibitors broussonetines C, O and P
(Elsevier, 2009)
The first syntheses of the polyhydroxylated alkaloids (iminosugars) broussonetines O and P, glycosidase inhibitors of the pyrrolidine class, have been performed in a convergent, stereocontrolled way from d-serine as the ...
Small Molecules as Toll-like Receptor 4 Modulators Drug and In-House Computational Repurposing
(MDPI, 2022-09)
The innate immunity toll-like receptor 4 (TLR4) system is a receptor of paramount importance as a therapeutic target. Virtual screening following a “computer-aided drug repurposing” approach was applied to the discovery ...
Stereoselective syntheses of the glycosidase inhibitors hyacinthacine A2, hyacinthacine A3 and 5-epi-hyacinthacine A3
(Elsevier, 2009)
Stereoselective syntheses of the naturally occurring glycosidase inhibitors hyacinthacines A2 and A3 are reported. In the case of hyacinthacine A2, the pyrrolizidine system was created from an acyclic precursor via a double ...
Bacterial base excision repair enzyme Fpg recognizes bulky N7-substituted-FapydG lesion via unproductive binding mode
(2012-07-18)
Fpg is a bacterial base excision repair enzyme that removes oxidized purines from DNA. This work shows that Fpg and its eukaryote homolog Ogg1 recognize with high affinity FapydG and bulky N7-benzyl-FapydG (Bz-FapydG). The ...
New chiral tetraaza ligands for the efficient enantioselective addition of dialkylzinc to aromatic aldehydes
(Elsevier, 2008)
A series of chiral tetraaza ligands were studied for the enantioselective addition of dialkylzinc to aldehydes. These bis(amino amide) ligands show high enantioselectivity in the addition of organozincs to aromatic aldehydes. ...
Synthesis of heterocycles compounds from condensation of limonene with aldehydes using heteropolyacids supported on metal oxides
(Elsevier, 2022-08)
In this contribution, heterogeneous materials based on heteropolyacids (HPA, H3PW12040 hydrate) supported over several metal oxides (TiO2, SiO2, SBA-15, Al2O3) were prepared using wetness impregnation, characterized by ...
Electro deposited In2S3 buffer layers for CuInS2 solar cells
(Elsevier, 2008)
We report the electro deposition of In2S3 buffer layers for CuInS2 solar cells. All materials and deposition conditions were selected taking into account environmental, economic and technological aspects of a potential ...