Vibrational Circular Dichroism Shows Reversible Helical Handedness Switching in Peptidomimetic l-Valine Fibrils
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http://dx.doi.org/10.1021/jz300725d |
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Títol
Vibrational Circular Dichroism Shows Reversible Helical Handedness Switching in Peptidomimetic l-Valine FibrilsAutoria
Data de publicació
2012Editor
American Chemical SocietyISSN
1948-7185Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://pubs.acs.org/doi/abs/10.1021%2Fjz300725dParaules clau / Matèries
Resum
We elucidate the supramolecular organization in the form of microsize fibrils of gels formed by a l-Valine peptidomimetic compound. Analysis was based on circular dichroism spectroscopies, vibrational (VCD) and ... [+]
We elucidate the supramolecular organization in the form of microsize fibrils of gels formed by a l-Valine peptidomimetic compound. Analysis was based on circular dichroism spectroscopies, vibrational (VCD) and electronic (CD), supported by microscopy (atomic force and scanning electron). We show how the VCD spectra give account of the micrometric structure of the fibrils formed by the helicoidal arrangement of simpler proto-fibrils, which are organized in a lower hierarchical level. This ability is used to monitorize a fully reversible change in the handedness of the helix by modulating different external stimuli as pH or ionic strength, thus providing the first observation by VCD of such a phenomenon in a short peptide. [-]
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