Executive functions profile in extreme eating/weight conditions: from anorexia nervosa to obesity
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comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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Title
Executive functions profile in extreme eating/weight conditions: from anorexia nervosa to obesityAuthor (s)
Date
2012Publisher
Public Library of ScienceType
info:eu-repo/semantics/articlePublisher version
http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjou ...Version
info:eu-repo/semantics/publishedVersionAbstract
Background: Extreme weight conditions (EWC) groups along a continuum may share some biological risk factors and
intermediate neurocognitive phenotypes. A core cognitive trait in EWC appears to be executive dysfunction, ... [+]
Background: Extreme weight conditions (EWC) groups along a continuum may share some biological risk factors and
intermediate neurocognitive phenotypes. A core cognitive trait in EWC appears to be executive dysfunction, with a focus on
decision making, response inhibition and cognitive flexibility. Differences between individuals in these areas are likely to
contribute to the differences in vulnerability to EWC. The aim of the study was to investigate whether there is a common
pattern of executive dysfunction in EWC while comparing anorexia nervosa patients (AN), obese subjects (OB) and healthy
eating/weight controls (HC).
Methods: Thirty five AN patients, fifty two OB and one hundred thirty seven HC were compared using the Wisconsin Card
Sorting Test (WCST); Stroop Color and Word Test (SCWT); and Iowa Gambling Task (IGT). All participants were female, aged
between 18 and 60 years.
Results: There was a significant difference in IGT score (F(1.79); p,.001), with AN and OB groups showing the poorest
performance compared to HC. On the WCST, AN and OB made significantly more errors than controls (F(25.73); p,.001),
and had significantly fewer correct responses (F(2.71); p,.001). Post hoc analysis revealed that the two clinical groups were
not significantly different from each other. Finally, OB showed a significant reduced performance in the inhibition response
measured with the Stroop test (F(5.11); p,.001) compared with both AN and HC.
Conclusions: These findings suggest that EWC subjects (namely AN and OB) have similar dysfunctional executive profile
that may play a role in the development and maintenance of such disorders [-]
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PLoS ONE, August, Volume 7, Issue 8, e43382Rights
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Except where otherwise noted, this item's license is described as © Fagundo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited