Rapid screening of arsenic species in urine from exposed human by inductively coupled plasma mass spectrometry with germanium as internal standard
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Other documents of the author: Castillo Tirado, Ángel; Fabregat-Cabello, Neus; Roig-Navarro, Antoni F.; Boix Sales, Clara; Rodríguez-Castrillón, J.A.
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/33596
comunitat-uji-handle3:10234/33597
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Title
Rapid screening of arsenic species in urine from exposed human by inductively coupled plasma mass spectrometry with germanium as internal standardAuthor (s)
Date
2012Publisher
Royal Society of ChemistryISSN
0267-9477; 1364-5544Bibliographic citation
J. Anal. At. Spectrom., 2012,27, 354-358Type
info:eu-repo/semantics/articlePublisher version
http://pubs.rsc.org/en/Content/ArticleLanding/2012/JA/C1JA10289CVersion
info:eu-repo/semantics/submittedVersionAbstract
In the present work, internal standardization based on species-unspecific isotope dilution analysis technique is proposed in order to overcome the matrix effects and signal drift originated in the speciation of As in ... [+]
In the present work, internal standardization based on species-unspecific isotope dilution analysis technique is proposed in order to overcome the matrix effects and signal drift originated in the speciation of As in urine by HPLC-ICP-MS. To this end, 72Ge has been selected as a pseudo-isotope of As. The resulting mass flow chromatogram of the element allows the calculation of the corrected overall species concentrations without requiring any methodological calibration, providing high-throughput sample processing. The validation was carried out by analyzing a blank human urine fortified at three concentration levels and an unspiked human urine sample containing different species of arsenic. In all cases, recoveries ranging from 90 to 115% and RSD below 10% were attained with this approach. Furthermore, the proposed method provided results in excellent agreement with those obtained using standard additions and internal standard calibration, allowing a fast way to assess human exposure to arsenic species. [-]
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Journal of Analytical Atomic Spectrometry, 2012, num. 27Rights
© Royal Society of Chemistry 2013
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