Age- and sex-related differences in the acquisition and reinstatement of ethanol CPP in mice
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Other documents of the author: Roger Sánchez, C.; Aguilar, M.A.; Rodriguez-Arias, Marta; González Aragón, Carlos Manuel; Miñarro, Josse
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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http://dx.doi.org/10.1016/j.ntt.2011.07.011 |
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Title
Age- and sex-related differences in the acquisition and reinstatement of ethanol CPP in miceAuthor (s)
Date
2012Publisher
ElsevierISSN
0892-0362Bibliographic citation
Neurotoxicology and Teratology (Jan.-Feb. 2012) vol. 34, no. 1, p. 108-115Type
info:eu-repo/semantics/articlePublisher version
http://www.sciencedirect.com/science/article/pii/S0892036211001607Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Many people begin to experiment with alcohol during adolescence, an important developmental period during which sex differences in the effects of ethanol appear. In the present study we evaluated the effect of ethanol ... [+]
Many people begin to experiment with alcohol during adolescence, an important developmental period during which sex differences in the effects of ethanol appear. In the present study we evaluated the effect of ethanol (0, 0.625, 1.25 or 2.5 g/kg) on the acquisition of a conditioned place preference (CPP) in early and late adolescent male and female mice. In addition, we assessed the capacity of ethanol to induce reinstatement of the CPP after its extinction. CPP was induced in early and late adolescent females with 2.5 g/kg, and in early adolescent males with 1.25 or 2.5 g/kg of ethanol. No CPP was observed in late adolescent males. Priming with ethanol reinstated the CPP induced by the highest dose in early adolescent male and early and late adolescent female mice. Our data suggest that early adolescents of both sex and late adolescent females are particularly vulnerable to the effects of ethanol. [-]
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© 2012 Elsevier Inc. All rights reserved
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