Age- and sex-related differences in the acquisition and reinstatement of ethanol CPP in mice
Impacte
Scholar |
Altres documents de l'autoria: Roger Sánchez, C.; Aguilar, M.A.; Rodriguez-Arias, Marta; González Aragón, Carlos Manuel; Miñarro, Josse
Metadades
Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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http://dx.doi.org/10.1016/j.ntt.2011.07.011 |
Metadades
Títol
Age- and sex-related differences in the acquisition and reinstatement of ethanol CPP in miceAutoria
Data de publicació
2012Editor
ElsevierISSN
0892-0362Cita bibliogràfica
Neurotoxicology and Teratology (Jan.-Feb. 2012) vol. 34, no. 1, p. 108-115Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://www.sciencedirect.com/science/article/pii/S0892036211001607Versió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
Many people begin to experiment with alcohol during adolescence, an important developmental period during which sex differences in the effects of ethanol appear. In the present study we evaluated the effect of ethanol ... [+]
Many people begin to experiment with alcohol during adolescence, an important developmental period during which sex differences in the effects of ethanol appear. In the present study we evaluated the effect of ethanol (0, 0.625, 1.25 or 2.5 g/kg) on the acquisition of a conditioned place preference (CPP) in early and late adolescent male and female mice. In addition, we assessed the capacity of ethanol to induce reinstatement of the CPP after its extinction. CPP was induced in early and late adolescent females with 2.5 g/kg, and in early adolescent males with 1.25 or 2.5 g/kg of ethanol. No CPP was observed in late adolescent males. Priming with ethanol reinstated the CPP induced by the highest dose in early adolescent male and early and late adolescent female mice. Our data suggest that early adolescents of both sex and late adolescent females are particularly vulnerable to the effects of ethanol. [-]
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© 2012 Elsevier Inc. All rights reserved
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info:eu-repo/semantics/restrictedAccess
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