Right parietal hypoactivation in a cocaine-dependent group during a verbal working memory task
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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http://dx.doi.org/10.1016/j.brainres.2010.12.042 |
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Title
Right parietal hypoactivation in a cocaine-dependent group during a verbal working memory taskAuthor (s)
Date
2011-02-23Publisher
ElsevierISSN
0006-8993Bibliographic citation
Brain Research (23 Febr. 2011), vol. 1375, p. 111-1119Type
info:eu-repo/semantics/articlePublisher version
http://www.sciencedirect.com/science/article/pii/S0006899310027071Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
It has been suggested that cocaine addiction affects the engagement of the frontoparietal networks in executive functions, such as attention and workingmemory. Thus, our objective was to investigate brain differences ... [+]
It has been suggested that cocaine addiction affects the engagement of the frontoparietal networks in executive functions, such as attention and workingmemory. Thus, our objective was to investigate brain differences between cocaine-dependent subjects and healthy controls during the performance ofaverbalworkingmemorytask. Nineteen comparison men and nineteen cocaine-dependent men performed a 2-back task. Data were acquired on a 1.5-T Siemens Avanto. Image processing and statistical analyses were carried out using SPM5; Biological Parametric Mapping (BPM) was used for further morphometric and correlation analyses. No performance differences were found between groups. However, the dorsal part of the right inferior parietal cortex (BA 40) was less activated in thecocaine-dependentgroup. Cocaine patients did not overactive any brain area when compared with controls. Our results show reduced activation in the brain areas related to the attention system incocaine-dependent men while performing averbalworkingmemorytask. Chronic cocaine use may affect the attentional system in the rightparietal lobe, making patients more prone to attentional deficits. [-]
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