Right parietal hypoactivation in a cocaine-dependent group during a verbal working memory task
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http://dx.doi.org/10.1016/j.brainres.2010.12.042 |
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Títol
Right parietal hypoactivation in a cocaine-dependent group during a verbal working memory taskAutoria
Data de publicació
2011-02-23Editor
ElsevierISSN
0006-8993Cita bibliogràfica
Brain Research (23 Febr. 2011), vol. 1375, p. 111-1119Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://www.sciencedirect.com/science/article/pii/S0006899310027071Versió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
It has been suggested that cocaine addiction affects the engagement of the frontoparietal networks in executive functions, such as attention and workingmemory. Thus, our objective was to investigate brain differences ... [+]
It has been suggested that cocaine addiction affects the engagement of the frontoparietal networks in executive functions, such as attention and workingmemory. Thus, our objective was to investigate brain differences between cocaine-dependent subjects and healthy controls during the performance ofaverbalworkingmemorytask. Nineteen comparison men and nineteen cocaine-dependent men performed a 2-back task. Data were acquired on a 1.5-T Siemens Avanto. Image processing and statistical analyses were carried out using SPM5; Biological Parametric Mapping (BPM) was used for further morphometric and correlation analyses. No performance differences were found between groups. However, the dorsal part of the right inferior parietal cortex (BA 40) was less activated in thecocaine-dependentgroup. Cocaine patients did not overactive any brain area when compared with controls. Our results show reduced activation in the brain areas related to the attention system incocaine-dependent men while performing averbalworkingmemorytask. Chronic cocaine use may affect the attentional system in the rightparietal lobe, making patients more prone to attentional deficits. [-]
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© 2010 Elsevier Inc. All rights reserved
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
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