A theoretical study on the decomposition mechanism of artemisinin
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Other documents of the author: Moles Tena, Pamela; Oliva, Mónica; Safont Villarreal, Vicent Sixte
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comunitat-uji-handle2:10234/7013
comunitat-uji-handle3:10234/8638
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http://dx.doi.org/10.1016/j.tet.2008.07.086 |
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Title
A theoretical study on the decomposition mechanism of artemisininDate
2008-09Publisher
ElsevierISSN
0040-4020Bibliographic citation
Tetrahedron, 64, 40, p. 9448-9463Type
info:eu-repo/semantics/articlePublisher version
http://www.sciencedirect.com/science/article/pii/S0040402008013744Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
A theoretical study on the artemisinin decomposition mechanism is reported. The suggested pathways have been reproduced and the appearance of the final products can be explained in a satisfactory way. In addition, ... [+]
A theoretical study on the artemisinin decomposition mechanism is reported. The suggested pathways have been reproduced and the appearance of the final products can be explained in a satisfactory way. In addition, several intermediates and radicals have been found as relatively stable species, thus giving support to the current hypothesis that some of these species can be responsible for the antimalarial action of artemisinin and its derivatives. [-]
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info:eu-repo/semantics/closedAccess
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