Enantioselective nickel-catalyzed conjugate addition of dialkylzinc to chalcones using chiral α-amino amides

dc.contributor.author	Escorihuela, Jorge
dc.contributor.author	Burguete, M. Isabel
dc.contributor.author	Luis, Santiago V.
dc.date.accessioned	2012-05-28T14:36:49Z
dc.date.available	2012-05-28T14:36:49Z
dc.date.issued	2008
dc.identifier	http://dx.doi.org/10.1016/j.tetlet.2008.09.120
dc.identifier.citation	Tetrahedron Letters, 49, 48, p. 6885-6888
dc.identifier.issn	404039
dc.identifier.uri	http://hdl.handle.net/10234/39027
dc.description.abstract	A series of α-amino amides derived from natural amino acids (alanine, valine, phenylalanine, isoleucine, and phenylglycine) have been synthesized and fully characterized. Their Ni(II) complexes prepared from Ni(acac)<sub>2</sub> catalyze the enantioselective conjugate addition of diethylzinc to chalcones in high yields and in good enantioselectivities (up to 84%). The side chain of the amino acid and the substituents in the amide nitrogen govern the enantioselectivity of the catalytic process. © 2008 Elsevier Ltd. All rights reserved.
dc.language.iso	eng
dc.publisher	Elsevier
dc.rights.uri	http://rightsstatements.org/vocab/CNE/1.0/	*
dc.subject	Alkyl zinc
dc.subject	Amino amides
dc.subject	Conjugate addition
dc.subject	Enantioselective catalysis
dc.subject	Nickel complexes
dc.title	Enantioselective nickel-catalyzed conjugate addition of dialkylzinc to chalcones using chiral α-amino amides
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	http://dx.doi.org/10.1016/j.tetlet.2008.09.120
dc.rights.accessRights	info:eu-repo/semantics/closedAccess

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