Enantioselective nickel-catalyzed conjugate addition of dialkylzinc to chalcones using chiral α-amino amides
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Otros documentos de la autoría: Escorihuela, Jorge; Burguete, M. Isabel; Luis, Santiago V.
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http://dx.doi.org/10.1016/j.tetlet.2008.09.120 |
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Título
Enantioselective nickel-catalyzed conjugate addition of dialkylzinc to chalcones using chiral α-amino amidesFecha de publicación
2008Editor
ElsevierISSN
404039Cita bibliográfica
Tetrahedron Letters, 49, 48, p. 6885-6888Tipo de documento
info:eu-repo/semantics/articlePalabras clave / Materias
Resumen
A series of α-amino amides derived from natural amino acids (alanine, valine, phenylalanine, isoleucine, and phenylglycine) have been synthesized and fully characterized. Their Ni(II) complexes prepared from Ni(acac ... [+]
A series of α-amino amides derived from natural amino acids (alanine, valine, phenylalanine, isoleucine, and phenylglycine) have been synthesized and fully characterized. Their Ni(II) complexes prepared from Ni(acac)<sub>2</sub> catalyze the enantioselective conjugate addition of diethylzinc to chalcones in high yields and in good enantioselectivities (up to 84%). The side chain of the amino acid and the substituents in the amide nitrogen govern the enantioselectivity of the catalytic process. © 2008 Elsevier Ltd. All rights reserved. [-]
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info:eu-repo/semantics/closedAccess
info:eu-repo/semantics/closedAccess
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