New chiral tetraaza ligands for the efficient enantioselective addition of dialkylzinc to aromatic aldehydes
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http://dx.doi.org/10.1016/j.tet.2008.07.099 |
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Títol
New chiral tetraaza ligands for the efficient enantioselective addition of dialkylzinc to aromatic aldehydesData de publicació
2008Editor
ElsevierISSN
404020Cita bibliogràfica
Tetrahedron, 64, 41, p. 9717-9724Tipus de document
info:eu-repo/semantics/articleResum
A series of chiral tetraaza ligands were studied for the enantioselective addition of dialkylzinc to aldehydes. These bis(amino amide) ligands show high enantioselectivity in the addition of organozincs to aromatic ... [+]
A series of chiral tetraaza ligands were studied for the enantioselective addition of dialkylzinc to aldehydes. These bis(amino amide) ligands show high enantioselectivity in the addition of organozincs to aromatic aldehydes. Different structural elements on the ligands seem to play an important role in determining the observed enantioselectivity. Ligand 4b (N,N′-bis(N-l-valinyl)-1,3-diaminopropane, with an aliphatic spacer with 3C atoms) catalyzed the addition of Et<sub>2</sub>Zn to benzaldehyde, 1-naphtaldehyde, 4-methoxybenzaldehyde, and 4-chlorobenzaldehyde to give the corresponding alcohol products with excellent conversions and selectivities and with enantioselectivities of 99, 97, 98, and 82%, respectively. DFT calculations provide an understanding of the mechanism of the enantioselection process. © 2008 Elsevier Ltd. All rights reserved. [-]
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