fMRI neurofeedback leads to long-term symptomatic reduction in treatment-resistant patients with obsessive-compulsive disorder
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comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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Title
fMRI neurofeedback leads to long-term symptomatic reduction in treatment-resistant patients with obsessive-compulsive disorderAuthor (s)
Date
2023Publisher
Cambridge University PressBibliographic citation
Ferreira S, Machado-Sousa M, Vieira R, et al. fMRI neurofeedback leads to long-term symptomatic reduction in treatment-resistant patients with obsessive-compulsive disorder. European Psychiatry. 2023;66(S1):S229-S230. doi:10.1192/j.eurpsy.2023.530Type
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info:eu-repo/semantics/publishedVersionAbstract
Introduction: Obsessive‐compulsive disorder (OCD) is a severe
condition with a profound impact on the health, social and professional functioning of the patients. More than one third of the
patients do not achieve ... [+]
Introduction: Obsessive‐compulsive disorder (OCD) is a severe
condition with a profound impact on the health, social and professional functioning of the patients. More than one third of the
patients do not achieve remission of the symptoms after first‐line
treatment with cognitive‐behavioral therapy and selective serotonin reuptake inhibitor medication. Neurofeedback is a promising
technique that allows the non‐invasive self‐regulation of neural
activity associated with symptomatic manifestation. Previous literature reported preliminary evidence of positive effects of functional magnetic resonance imaging (fMRI) neurofeedback on OCD
symptoms. However, these studies have small samples and/or were
not controlled. Additionally, these studies did not involve treatment‐resistant patients.
Objectives: We aim at developing a fMRI neurofeedback task to
treatment-resistant OCD patients and to explore the underlying
brain changes.
Methods: We implemented a sham‐controlled double‐blinded
fMRI neurofeedback protocol to target hyperactivity in orbitofrontal regions in treatment‐resistant OCD patients with contamination/cleaning symptoms. The protocol had two sessions of
neurofeedback (72 min of total training). The patients included
were under treatment‐as‐usual.
Results: Our preliminary results with the experimental group (n =
10 patients) demonstrated decreased OCD and stress symptoms
three months after the neurofeedback sessions. Moreover, immediately after the neurofeedback sessions, we observed reduced
functional connectivity between orbitofrontal and temporoparietal
regions, and increased brain activity in dorsolateral prefrontal and
premotor areas during symptomatic provocation. The brain functional changes might be associated with a better control over
obsessions.
Conclusions: fMRI neurofeedback led to long-term symptomatic
reduction in treatment-resistant patients with OCD. Our results
need further validation with the sham‐control group but highlight
the efficacy of fMRI neurofeedback for refractory OCD and the
necessity of prolonged neurofeedback protocols. [-]
Is part of
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S229 - S230Rights
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