Workflow to facilitate the detection of new psychoactive substances and drugs of abuse in influent urban wastewater
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Otros documentos de la autoría: Bade, Richard; van Herwerden, Denice; Rousis, Nikolaos I; Adhikari, Sangeet; Allen, Darren; Baduel, Christine; Bijlsma, Lubertus; Boogaerts, Tim; Burgard, Dan; Chappell, Andrew; Driver, Erin M.; Fabriz Sodré, Fernando; Fatta-Kassinos, Despo; GRACIA LOR, EMMA; Gracia-Marín, Elisa; Halden, Rolf; Heath, Ester; Keller, Emma; Krotulski, Alex; Lai, Foon Yin; Mueller, Jochen
Metadatos
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comunitat-uji-handle2:10234/33596
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INVESTIGACIONMetadatos
Título
Workflow to facilitate the detection of new psychoactive substances and drugs of abuse in influent urban wastewaterAutoría
Fecha de publicación
2024-03-08Editor
ElsevierISSN
0304-3894; 1873-3336Cita bibliográfica
Bade, R., van Herwerden, D., Rousis, N., Adhikari, S., Allen, D., Baduel, C., ... & Mueller, J. (2024). Workflow to facilitate the detection of new psychoactive substances and drugs of abuse in influent urban wastewater. Journal of Hazardous Materials, 133955.Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
The complexity around the dynamic markets for new psychoactive substances (NPS) forces researchers to develop and apply innovative analytical strategies to detect and identify them in influent urban wastewater. In ... [+]
The complexity around the dynamic markets for new psychoactive substances (NPS) forces researchers to develop and apply innovative analytical strategies to detect and identify them in influent urban wastewater. In this work a comprehensive suspect screening workflow following liquid chromatography – high resolution mass spectrometry analysis was established utilising the open-source InSpectra data processing platform and the HighResNPS library. In total, 278 urban influent wastewater samples from 47 sites in 16 countries were collected to investigate the presence of NPS and other drugs of abuse. A total of 50 compounds were detected in samples from at least one site. Most compounds found were prescription drugs such as gabapentin (detection frequency 79%), codeine (40%) and pregabalin (15%). However, cocaine was the most found illicit drug (83%), in all countries where samples were collected apart from the Republic of Korea and China. Eight NPS were also identified with this protocol: 3-methylmethcathinone 11%), eutylone (6%), etizolam (2%), 3-chloromethcathinone (4%), mitragynine (6%), phenibut (2%), 25I-NBOH (2%) and trimethoxyamphetamine (2%). The latter three have not previously been reported in municipal wastewater samples. The workflow employed allowed the prioritisation of features to be further investigated, reducing processing time and gaining in confidence in their identification. [-]
Publicado en
Journal of Hazardous Materials 469 (2024) 133955Datos relacionados
https://www.sciencedirect.com/science/article/pii/S030438942400534X#sec0115Entidad financiadora
Queensland Department of Health. R. B. | Australian Research Council Australian Laureate Fellowship | Australian Government | Australian Research Council (ARC) | Ministerio de Ciencia, Innovación y Universidades | SENAD/UnB | Flanders Research Foundation | Slovenian Research Agency (ARIS) | ARIS-Flanders Research Foundation | National Institute of Justice, Office of Justice Programs, U.S. Department of Justice | Gobierno de Madrid | European Union – NextGenerationEU
Código del proyecto o subvención
DE220100381 | FL200100028 | DP190102476 | EL1 2009209 | RYC2020–028936-I | MCIN/AEI/ 10.13039/501100011033 | TED 04/2020 | 1225924N | P1–0143 | N1–0143 | 15PNIJ-22-GG-04434-MUMU | PR65/19–22432 | EXP2022/008817
Derechos de acceso
0304-3894/© 2024 The Author(s). Published by Elsevier B.V.
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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