Tracing diurnal differences in brain anatomy with voxel-based morphometry - associations with sleep characteristics
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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INVESTIGACIONMetadata
Title
Tracing diurnal differences in brain anatomy with voxel-based morphometry - associations with sleep characteristicsAuthor (s)
Date
2024-01-08Publisher
Taylor & FrancisBibliographic citation
Michal Rafal Zareba, Magdalena Fafrowicz, Tadeusz Marek, Halszka Oginska, Ewa Beldzik & Aleksandra Domagalik (2024) Tracing diurnal differences in brain anatomy with voxel-based morphometry - associations with sleep characteristics, Chronobiology International, DOI: 10.1080/07420528.2024.2301944Type
info:eu-repo/semantics/articleVersion
info:eu-repo/semantics/acceptedVersionSubject
Abstract
Multiple aspects of brain functioning, including arousal, motivation, and cognitive performance, are governed by circadian rhythmicity. Although the recent rise in the use of magnetic resonance imaging (MRI) has enabled ... [+]
Multiple aspects of brain functioning, including arousal, motivation, and cognitive performance, are governed by circadian rhythmicity. Although the recent rise in the use of magnetic resonance imaging (MRI) has enabled investigations into the macroscopic correlates of the diurnal brain processes, neuroanatomical studies are scarce. The current work investigated how time-of-day (TOD) impacts white (WM) and grey matter (GM) volumes using voxel-based morphometry (VBM) in a large dataset (N = 72) divided into two equal, comparable subsamples to assess the replicability of effects. Furthermore, we aimed to assess how the magnitude of these diurnal differences was related to actigraphy-derived indices of sleep health. The results extend the current knowledge by reporting that TOD is predominantly associated with regional WM volume decreases. Additionally, alongside corroborating previously observed volumetric GM decreases, we provide the first evidence for positive TOD effects. Higher replicability was observed for WM, with the only two replicated GM clusters being volumetric increases in the amygdala and hippocampus, and decreases in the retrosplenial cortex, with the latter more pronounced in individuals with shorter sleep times. These findings implicate the existence of region-specific mechanisms behind GM effects, which might be related to cognitive processes taking place during wakefulness and homeostatic sleep pressure. [-]
Funder Name
National Science Centre, Poland (NCN)
Project code
2013/08/M/HS6/00042
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Copyright © 2024 Taylor & Francis
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- PSB_Articles [1321]