Tools and new metric (Macrocyclization Environmental Impact - MEI) to tackle the sustainability of macrocyclization reactions
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
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INVESTIGACIONMetadata
Title
Tools and new metric (Macrocyclization Environmental Impact - MEI) to tackle the sustainability of macrocyclization reactionsDate
2023-10-06Publisher
ElsevierBibliographic citation
ESTEVE, Ferran, et al. Tools and new metric (Macrocyclization Environmental Impact-MEI) to tackle the sustainability of macrocyclization reactions. Catalysis Today, 2024, vol. 426, p. 114407.Type
info:eu-repo/semantics/articleVersion
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Abstract
Albeit the numerous scientific advantages provided by macrocyclic compounds, there is still a significant gap between the “proof of concept” research and their application. This is a direct consequence of the challenging ... [+]
Albeit the numerous scientific advantages provided by macrocyclic compounds, there is still a significant gap between the “proof of concept” research and their application. This is a direct consequence of the challenging macrocyclization reactions generally involved in their production. Indeed, macrocyclizations are against the principles of Green Chemistry, as long reaction times, high dilution conditions, and solvent-consuming purification techniques are commonly needed. However, new tools -catalysts, templates, preorganization, flow chemistry- are blossoming to develop environmentally friendly approaches for synthesizing macrocycles. Here, we present some of these tools together with a simple metric to assess the environmental impact of several reported macrocyclic systems. The metric has been proved as a useful way to scrutinize macrocyclizations, even in the cases where other environmental metrics such as E-Factor and Emac did not show conclusive results. [-]
Funder Name
Universitat Jaume I | Generalitat Valenciana | FEDER/Ministerio de Ciencia e Innovación – Agencia Estatal de Investigación | Fundación Ramón Areces
Project code
UJI-B2019–40 | UJI-B2021–31 | AICO/2021/139 | RTI2018–098233-B-C22
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