Assessment of SARS-CoV-2 neutralizing antibody titers in breastmilk from convalescent and vaccinated mothers
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Other documents of the author: Bäuerl, Christine; Zulaica, Joao; Rusu, Luciana; Rodríguez Moreno, Alicia; Pérez-Cano, Francisco J; Lerin, Carles; Mena Tudela, Desirée; Aguilar, Laia; PARRA LLORCA, ANNA; Martinez-Costa, Cecilia; Geller, Ron; COLLADO, MARIA CARMEN
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Title
Assessment of SARS-CoV-2 neutralizing antibody titers in breastmilk from convalescent and vaccinated mothersAuthor (s)
Date
2023-06-16Publisher
ElsevierISSN
2589-0042Bibliographic citation
Christine Bäuerl, Joao Zulaica, Luciana Rusu, Alicia Rodríguez Moreno, Francisco J. Pérez-Cano, Carles Lerin, Desirée Mena-Tudela, Laia Aguilar-Camprubí, Anna Parra-Llorca, Cecilia Martínez-Costa, Ron Geller, Maria Carmen Collado, Assessment of SARS-CoV-2 neutralizing antibody titers in breastmilk from convalescent and vaccinated mothers, iScience, Volume 26, Issue 6, 2023, 106802.Type
info:eu-repo/semantics/articleVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
Breastmilk contains antibodies that could protect breastfed infants from infections. In this work, we examined if antibodies in breastmilk could neutralize SARS-CoV-2 in 84 breastmilk samples from women that were ... [+]
Breastmilk contains antibodies that could protect breastfed infants from infections. In this work, we examined if antibodies in breastmilk could neutralize SARS-CoV-2 in 84 breastmilk samples from women that were either vaccinated (Comirnaty, mRNA-1273, or ChAdOx1), infected with SARS-CoV-2, or both infected and vaccinated. The neutralization capacity of these sera was tested using pseudotyped vesicular stomatitis virus carrying either the Wuhan-Hu-1, Delta, or BA.1 Omicron spike proteins. We found that natural infection resulted in higher neutralizing titers and that neutralization correlated positively with levels of immunoglobulin A in breastmilk. In addition, significant differences in the capacity to produce neutralizing antibodies were observed between both mRNA-based vaccines and the adenovirus-vectored ChAdOx1 COVID-19 vaccine. Overall, our results indicate that breastmilk from naturally infected women or those vaccinated with mRNA-based vaccines contains SARS-CoV-2 neutralizing antibodies that could potentially provide protection to breastfed infants from infection. [-]
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iScience, Volume 26, Issue 6 (2023)Funder Name
European Commission NextGenerationEU
Project code
EU 2020/2094
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© 2023 The Author(s)
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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