Application of micellar liquid chromatographic method for rapid screening of ceftriaxone, metronidazole, amoxicillin, amikacin and ciprofloxacin in hospital wastewater from Sagar District, India
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Altres documents de l'autoria: Sharma, Dr Girraj; Pahade, Priyanka; Durgbanshi, Abhilasha; Carda-Broch, Samuel; Peris Vicente, Juan; Bose, Devasish
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Títol
Application of micellar liquid chromatographic method for rapid screening of ceftriaxone, metronidazole, amoxicillin, amikacin and ciprofloxacin in hospital wastewater from Sagar District, IndiaAutoria
Data de publicació
2022-06Editor
ElsevierISSN
2772-8099Cita bibliogràfica
2772-8099Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://www.sciencedirect.com/science/article/pii/S277280992200003XVersió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
The present research work mainly highlights the simultaneous detection of five antibiotics i.e., ceftriaxone (CTX),
metronidazole (MTZ), amoxicillin (AMX), amikacin (AMK) and ciprofloxacin (CPFX) in hospital wastew ... [+]
The present research work mainly highlights the simultaneous detection of five antibiotics i.e., ceftriaxone (CTX),
metronidazole (MTZ), amoxicillin (AMX), amikacin (AMK) and ciprofloxacin (CPFX) in hospital wastewater
located in Sagar district (Madhya Pradesh, India). All these antibiotics make their way through drainage systems
into the environment in the form of metabolized and unmetabolized compounds. Growing concern about the
antibiotic resistance and contamination of wastewater by antibiotics requires fast, sensitive and eco‐friendly techniques. Therefore a simple, rapid and eco‐friendly chromatographic method has been developed for simultaneous
determination of CTX, MTZ, AMX, AMK and CPFX in hospital wastewater samples. Optimization of the method
was accomplished using response surface methodology (RSM) with Box‐Behnken design (BBD). The optimized
mobile phase was 0.15 M SDS‐0.01 M NaH2PO4‐7% (v/v) 1‐butanol, pH 3 which provided a chromatographic
run time of 11 min. for the simultaneous determination of selected antibiotics. The correlation coefficient (r2
) values were satisfactory between 0.996 and 0.999 over the linear concentration range of 0.04–12 μg/mL. Limits of
detection (LODs) and the limits of quantification (LOQs) for the five antibiotics were in the range of 0.02–0.18 μg/
mL and 0.04–0.25 μg/mL, respectively. The developed method is simple, rapid, cost‐effective and green which
could be used for complex matrix (wastewater) without any sample pretreatment other than filtration. The results
indicated that the MLC‐PDA method proved to be more suitable than reverse phase‐high performance liquid chromatography for the simultaneous separation of selected antibiotics. [-]
Publicat a
Total Environment Research Themes, vols. 1–2, (2022)Drets d'accés
info:eu-repo/semantics/openAccess
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