Nucleus incertus projections to rat medial septum and entorhinal cortex: rare collateralization and septal-gating of temporal lobe theta rhythm activity
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INVESTIGACIONMetadata
Title
Nucleus incertus projections to rat medial septum and entorhinal cortex: rare collateralization and septal-gating of temporal lobe theta rhythm activityAuthor (s)
Date
2023Publisher
SpringerISSN
1863-2653; 1863-2661Bibliographic citation
Gil-Miravet, I., Núñez-Molina, Á., Navarro-Sánchez, M. et al. Nucleus incertus projections to rat medial septum and entorhinal cortex: rare collateralization and septal-gating of temporal lobe theta rhythm activity. Brain Struct Funct 228, 1307–1328 (2023). https://doi.org/10.1007/s00429-023-02650-xType
info:eu-repo/semantics/articlePublisher version
https://link.springer.com/article/10.1007/s00429-023-02650-xVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
Nucleus incertus (NI) neurons in the pontine tegmentum give rise to ascending forebrain projections and express the neuropeptide relaxin-3 (RLN3) which acts via the relaxin-family peptide 3 receptor (RXFP3). Activity ... [+]
Nucleus incertus (NI) neurons in the pontine tegmentum give rise to ascending forebrain projections and express the neuropeptide relaxin-3 (RLN3) which acts via the relaxin-family peptide 3 receptor (RXFP3). Activity in the hippocampus and entorhinal cortex can be driven from the medial septum (MS), and the NI projects to all these centers, where a prominent pattern of activity is theta rhythm, which is related to spatial memory processing. Therefore, we examined the degree of collateralization of NI projections to the MS and the medial temporal lobe (MTL), comprising medial and lateral entorhinal cortex (MEnt, LEnt) and dentate gyrus (DG), and the ability of the MS to drive entorhinal theta in the adult rat. We injected fluorogold and cholera toxin-B into the MS septum and either MEnt, LEnt or DG, to determine the percentage of retrogradely labeled neurons in the NI projecting to both or single targets, and the relative proportion of these neurons that were RLN3-positive ( +). The projection to the MS was threefold stronger than that to the MTL. Moreover, a majority of NI neurons projected independently to either MS or the MTL. However, RLN3 + neurons collateralize significantly more than RLN3-negative (–) neurons. In in vivo studies, electrical stimulation of the NI induced theta activity in the MS and the entorhinal cortex, which was impaired by intraseptal infusion of an RXFP3 antagonist, R3(BΔ23-27)R/I5, particularly at ~ 20 min post-injection. These findings suggest that the MS plays an important relay function in the NI-induced generation of theta within the entorhinal cortex. [-]
Is part of
Brain Structure and Function, 2023, vol 228Related data
http://hdl.handle.net/10234/201305Funder Name
Ministerio de Ciencia, Innovación y Universidades | Generalitat Valenciana | Fundación Alicia Koplowitz | National Health and Medical Research Council of Australia | Universitat Jaume I
Funder ID
http://dx.doi.org/10.13039/501100011033
Project code
MICIU/ICTI2017-2020/RTI2018-095698-B-I00 | MICIU/ICTI2017-2020/PID2019-107809RB-I00 | AICO/2021/246 | 19I436 | 1067522 | PREDOC/2021/19 | POSDOC/2021/19 | UJI-A2017-17 | UJI-B2019-54
Project title or grant
Desarrollo de sistemas peptidérgicos relacionados con comportamiento social. la interacción relaxin3-oxitocina | Modulación por IGFI de la plasticidad sináptica en la corteza somestésica del ratón. Alteraciones en modelos de la enfermedad de Alzheimer y en diabetes
Rights
info:eu-repo/semantics/openAccess
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- MED_Articles [662]