Postnatal development of the relaxin-3 innervation of the rat medial septum
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Otros documentos de la autoría: ROS, FRANCISCO; Gil-Miravet, Isis; Lucerón Morales, Jorge; Navarro Sánchez, Mónica; Castillo-Gómez, Esther; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E
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Título
Postnatal development of the relaxin-3 innervation of the rat medial septumAutoría
Fecha de publicación
2023Editor
Frontiers MediaISSN
1662-4548; 1662-453XCita bibliográfica
Ros-Bernal F, Gil-Miravet I, Lucerón J, Navarro-Sánchez M, Castillo-Gómez E, Gundlach AL and Olucha-Bordonau FE (2023) Postnatal development of the relaxin-3 innervation of the rat medial septum. Front. Neurosci. 17:1176587. doi: 10.3389/fnins.2023.1176587Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Introduction: The septal area provides a rich innervation to the hippocampus
regulating hippocampal excitability to different behavioral states and modulating
theta rhythmogenesis. However, little is known about the ... [+]
Introduction: The septal area provides a rich innervation to the hippocampus
regulating hippocampal excitability to different behavioral states and modulating
theta rhythmogenesis. However, little is known about the neurodevelopmental
consequences of its alterations during postnatal development. The activity of
the septohippocampal system is driven and/or modulated by ascending inputs,
including those arising from the nucleus incertus (NI), many of which contain the
neuropeptide, relaxin-3 (RLN3).
Methods: We examined at the molecular and cellular level the ontogeny of RLN3
innervation of the septal area in postnatal rat brains.
Results: Up until P13–15 there were only scattered fibers in the septal area, but a
dense plexus had appeared by P17 that was extended and consolidated throughout
the septal complex by P20. There was a decrease in the level of colocalization
of RLN3 and synaptophysin between P15 and P20 that was reversed between
P20 and adulthood. Biotinylated 3-kD dextran amine injections into the septum,
revealed retrograde labeling present in the brainstem at P10-P13, but a decrease
in anterograde fibers in the NI between P10–20. Simultaneously, a differentiation
process began during P10–17, resulting in fewer NI neurons double-labeled for
serotonin and RLN3.
Discussion: The onset of the RLN3 innervation of the septum complex between
P17–20 is correlated with the onset of hippocampal theta rhythm and several
learning processes associated with hippocampal function. Together, these data
highlight the relevance and need for further analysis of this stage for normal and
pathological septohippocampal development. [-]
Publicado en
Frontiers in Neuroscience 17:1176587Entidad financiadora
Fundación Alicia Koplowitz | Ministerio de Ciencia, Innovación y Universidades | Generalitat Valenciana | Universitat Jaume I
Código del proyecto o subvención
19I436 (FO-B, FR-B, EC-G) | RTI2018-095698-B-I00 (FO-B, EC-G, FR-B, IG-M) | AICO/2021/246 (FO-B, FR-B, EC-G) | PREDOC/2021/19 (MN-S) | POSDOC/2021/19 (IG-M) | UJI-A2017-17 (FR-B) | UJI-B2019-54 (FO-B) | UJI-A2020-20 (EC-G)
Derechos de acceso
info:eu-repo/semantics/openAccess
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