Postnatal development of the relaxin-3 innervation of the rat medial septum
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Other documents of the author: ROS, FRANCISCO; Gil-Miravet, Isis; Lucerón Morales, Jorge; Navarro Sánchez, Mónica; Castillo-Gómez, Esther; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E
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INVESTIGACIONMetadata
Title
Postnatal development of the relaxin-3 innervation of the rat medial septumAuthor (s)
Date
2023Publisher
Frontiers MediaISSN
1662-4548; 1662-453XBibliographic citation
Ros-Bernal F, Gil-Miravet I, Lucerón J, Navarro-Sánchez M, Castillo-Gómez E, Gundlach AL and Olucha-Bordonau FE (2023) Postnatal development of the relaxin-3 innervation of the rat medial septum. Front. Neurosci. 17:1176587. doi: 10.3389/fnins.2023.1176587Type
info:eu-repo/semantics/articleVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
Introduction: The septal area provides a rich innervation to the hippocampus
regulating hippocampal excitability to different behavioral states and modulating
theta rhythmogenesis. However, little is known about the ... [+]
Introduction: The septal area provides a rich innervation to the hippocampus
regulating hippocampal excitability to different behavioral states and modulating
theta rhythmogenesis. However, little is known about the neurodevelopmental
consequences of its alterations during postnatal development. The activity of
the septohippocampal system is driven and/or modulated by ascending inputs,
including those arising from the nucleus incertus (NI), many of which contain the
neuropeptide, relaxin-3 (RLN3).
Methods: We examined at the molecular and cellular level the ontogeny of RLN3
innervation of the septal area in postnatal rat brains.
Results: Up until P13–15 there were only scattered fibers in the septal area, but a
dense plexus had appeared by P17 that was extended and consolidated throughout
the septal complex by P20. There was a decrease in the level of colocalization
of RLN3 and synaptophysin between P15 and P20 that was reversed between
P20 and adulthood. Biotinylated 3-kD dextran amine injections into the septum,
revealed retrograde labeling present in the brainstem at P10-P13, but a decrease
in anterograde fibers in the NI between P10–20. Simultaneously, a differentiation
process began during P10–17, resulting in fewer NI neurons double-labeled for
serotonin and RLN3.
Discussion: The onset of the RLN3 innervation of the septum complex between
P17–20 is correlated with the onset of hippocampal theta rhythm and several
learning processes associated with hippocampal function. Together, these data
highlight the relevance and need for further analysis of this stage for normal and
pathological septohippocampal development. [-]
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Frontiers in Neuroscience 17:1176587Funder Name
Fundación Alicia Koplowitz | Ministerio de Ciencia, Innovación y Universidades | Generalitat Valenciana | Universitat Jaume I
Project code
19I436 (FO-B, FR-B, EC-G) | RTI2018-095698-B-I00 (FO-B, EC-G, FR-B, IG-M) | AICO/2021/246 (FO-B, FR-B, EC-G) | PREDOC/2021/19 (MN-S) | POSDOC/2021/19 (IG-M) | UJI-A2017-17 (FR-B) | UJI-B2019-54 (FO-B) | UJI-A2020-20 (EC-G)
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