Neural Stem Cells as Potential Glioblastoma Cells of Origin
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Other documents of the author: Loras Monfort, Alba; Gonzalez Bonet, Luis Germán; Gutierrez-Arroyo, Julia L.; Martinez-Cadenas, Conrado; Marques-Torrejon, Maria Angeles
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Title
Neural Stem Cells as Potential Glioblastoma Cells of OriginAuthor (s)
Date
2023Publisher
MDPIBibliographic citation
Loras, A.; Gonzalez-Bonet, L.G.; Gutierrez-Arroyo, J.L.; Martinez-Cadenas, C.; Marques-Torrejon, M.A. Neural Stem Cells as Potential Glioblastoma Cells of Origin. Life 2023, 13, 905. https:// doi.org/10.3390/life13040905Type
info:eu-repo/semantics/articlePublisher version
https://www.mdpi.com/2075-1729/13/4/905Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Glioblastoma multiforme (GBM) is the most malignant brain tumor in adults and it remains
incurable. These tumors are very heterogeneous, resistant to cytotoxic therapies, and they show high
rates of invasiveness. ... [+]
Glioblastoma multiforme (GBM) is the most malignant brain tumor in adults and it remains
incurable. These tumors are very heterogeneous, resistant to cytotoxic therapies, and they show high
rates of invasiveness. Therefore, patients face poor prognosis, and the survival rates remain very
low. Previous research states that GBM contains a cell population with stem cell characteristics called
glioma stem cells (GSCs). These cells are able to self-renew and regenerate the tumor and, therefore,
they are partly responsible for the observed resistance to therapies and tumor recurrence. Recent data
indicate that neural stem cells (NSCs) in the subventricular zone (SVZ) are the cells of origin of GBM,
that is, the cell type acquiring the initial tumorigenic mutation. The involvement of SVZ-NSCs is also
associated with GBM progression and recurrence. Identifying the cellular origin of GBM is important
for the development of early detection techniques and the discovery of early disease markers. In this
review, we analyze the SVZ-NSC population as a potential GBM cell of origin, and its potential role
for GBM therapies. [-]
Is part of
Life, 2023.Funder Name
"Margarita Salas" postdoctoral contract | 'Maria Zambrano' research contract | European Union-Next generation EU
Project code
21-076 | MAZ/2021/03 UP2021-021
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