Continuous-Flow Supercritical CO2 Platform for In-Situ Synthesis and Purification of Small Molecules for Drug Discovery
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comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
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INVESTIGACIONMetadata
Title
Continuous-Flow Supercritical CO2 Platform for In-Situ Synthesis and Purification of Small Molecules for Drug DiscoveryAuthor (s)
Date
2023-02-03Publisher
American Chemical SocietyBibliographic citation
ALCALDE, Sergio, et al. Continuous-Flow Supercritical CO2 Platform for In-Situ Synthesis and Purification of Small Molecules for Drug Discovery. Organic Process Research & Development, 2023, vol. 27, no 2, p. 276-285.Type
info:eu-repo/semantics/articlePublisher version
https://pubs.acs.org/doi/full/10.1021/acs.oprd.2c00253Version
info:eu-repo/semantics/acceptedVersionSubject
Abstract
The use of supercritical CO2 (scCO2) as an enabling technology paves the way for an efficient in-line integration of
the synthesis and purification of organic molecules. The scCO2 platform presented here provides a ... [+]
The use of supercritical CO2 (scCO2) as an enabling technology paves the way for an efficient in-line integration of
the synthesis and purification of organic molecules. The scCO2 platform presented here provides a streamlined process to produce a
diverse family of triazoles, common drug precursors, by 1,3-dipolar copper-catalyzed azide-alkyne cycloaddition (CuAAC, Huisgen
reaction), also decreasing the environmental impact by significantly reducing the use of traditional solvents. To further exemplify the
potential of this scCO2 platform, the synthesis and purification of rufinamide, a drug used to treat seizures associated with Lennox−
Gastaut syndrome, is also reported. [-]
Is part of
Organic Process Research & Development, 2023, vol. 27, no 2.Funder Name
Ministerio de Ciencia e Innovación | Universitat Jaume I | Generalitat Valenciana | Centro de Investigación Lilly S.A.
Project code
PID2021- 124695OB-C22 | UJIB2019-40 | AICO/2021/139
Rights
© 2023 American Chemical Society. "This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Process Research and Development, copyright © 2023 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/full/10.1021/acs.oprd.2c00253."
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info:eu-repo/semantics/openAccess
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