A Semantic Cognition Contribution to Mood and Anxiety Disorder Pathophysiology
![Thumbnail](/xmlui/bitstream/handle/10234/202663/85127.pdf.jpg?sequence=4&isAllowed=y)
View/ Open
Metadata
Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
comunitat-uji-handle4:
INVESTIGACIONMetadata
Title
A Semantic Cognition Contribution to Mood and Anxiety Disorder PathophysiologyDate
2023Publisher
MDPIISSN
2227-9032Bibliographic citation
González-García, I.; Visser, M. A Semantic Cognition Contribution to Mood and Anxiety Disorder Pathophysiology. Healthcare 2023, 11, 821. https://doi.org/ 10.3390/healthcare11060821Type
info:eu-repo/semantics/articleVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
Over the last two decades, the functional role of the bilateral anterior temporal lobes (bATLs)
has been receiving more attention. They have been associated with semantics and social concept
processing, and are ... [+]
Over the last two decades, the functional role of the bilateral anterior temporal lobes (bATLs)
has been receiving more attention. They have been associated with semantics and social concept
processing, and are regarded as a core region for depression. In the past, the role of the ATL has often
been overlooked in semantic models based on functional magnetic resonance imaging (fMRI) due to
geometric distortions in the BOLD signal. However, previous work has unequivocally associated the
bATLs with these higher-order cognitive functions following advances in neuroimaging techniques
to overcome the geometric distortions. At the same time, the importance of the neural basis of
conceptual knowledge in understanding mood disorders became apparent. Theoretical models of
the neural basis of mood and anxiety disorders have been classically studied from the emotion
perspective, without concentrating on conceptual processing. However, recent work suggests that
the ATL, a brain region underlying conceptual knowledge, plays an essential role in mood and
anxiety disorders. Patients with anxiety and depression often cope with self-blaming biases and
guilt. The theory is that in order to experience guilt, the brain needs to access the related conceptual
information via the ATL. This narrative review describes how aberrant interactions of the ATL with
the fronto–limbic emotional system could underlie mood and anxiety disorders. [-]
Is part of
Healthcare 2023, 11, 821Funder Name
Agencia Estatal de Investigación (AEI) | Valencian Community | University Jaume I
Project code
MCIN/AEI/10.13039/501100011033 | RYC2019-028370-I | PID2021-127516NB-I00 | CIAICO/2021/088 | UJI-B2022-55
Rights
info:eu-repo/semantics/openAccess
This item appears in the folowing collection(s)
- PSB_Articles [1320]