Sweet Taste Preference: Relationships with Other Tastes, Liking for Sugary Foods and Exploratory Genome-Wide Association Analysis in Subjects with Metabolic Syndrome
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comunitat-uji-handle2:10234/7038
comunitat-uji-handle3:10234/8634
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Title
Sweet Taste Preference: Relationships with Other Tastes, Liking for Sugary Foods and Exploratory Genome-Wide Association Analysis in Subjects with Metabolic SyndromeAuthor (s)
Date
2022-01Publisher
MDPIISSN
2227-9059Bibliographic citation
Fernández-Carrión, R.; Sorlí, J.V.; Coltell, O.; Pascual, E.C.; Ortega-Azorín, C.; Barragán, R.; Giménez-Alba, I.M.; Alvarez-Sala, A.; Fitó, M.; Ordovas, J.M.; Corella, D. Sweet Taste Preference: Relationships with Other Tastes, Liking for Sugary Foods and Exploratory Genome-Wide Association Analysis in Subjects with Metabolic Syndrome. Biomedicines 2022, 10, 79. https://doi.org/10.3390/biomedicines10010079Type
info:eu-repo/semantics/articlePublisher version
https://www.mdpi.com/2227-9059/10/1/79Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Taste perception and its association with nutrition and related diseases (type 2 diabetes, obesity, metabolic syndrome, cardiovascular, etc.) are emerging fields of biomedicine. There is currently great interest in ... [+]
Taste perception and its association with nutrition and related diseases (type 2 diabetes, obesity, metabolic syndrome, cardiovascular, etc.) are emerging fields of biomedicine. There is currently great interest in investigating the environmental and genetic factors that influence sweet taste and sugary food preferences for personalized nutrition. Our aims were: (1) to carry out an integrated analysis of the influence of sweet taste preference (both in isolation and in the context of other tastes) on the preference for sugary foods and its modulation by type 2 diabetes status; (2) as well as to explore new genetic factors associated with sweet taste preference. We studied 425 elderly white European subjects with metabolic syndrome and analyzed taste preference, taste perception, sugary-foods liking, biochemical and genetic markers. We found that type 2 diabetic subjects (38%) have a small, but statistically higher preference for sweet taste (p = 0.021) than non-diabetic subjects. No statistically significant differences (p > 0.05) in preferences for the other tastes (bitter, salty, sour or umami) were detected. For taste perception, type 2 diabetic subjects have a slightly lower perception of all tastes (p = 0.026 for the combined “total taste score”), bitter taste being statistically lower (p = 0.023). We also carried out a principal component analysis (PCA), to identify latent variables related to preferences for the five tastes. We identified two factors with eigenvalues >1. Factor 2 was the one with the highest correlation with sweet taste preference. Sweet taste preference was strongly associated with a liking for sugary foods. In the exploratory SNP-based genome-wide association study (GWAS), we identified some SNPs associated with sweet taste preference, both at the suggestive and at the genome-wide level, especially a lead SNP in the PTPRN2 (Protein Tyrosine Phosphatase Receptor Type N2) gene, whose minor allele was associated with a lower sweet taste preference. The PTPRN2 gene was also a top-ranked gene obtained in the gene-based exploratory GWAS analysis. In conclusion, sweet taste preference was strongly associated with sugary food liking in this population. Our exploratory GWAS identified an interesting candidate gene related with sweet taste preference, but more studies in other populations are required for personalized nutrition. [-]
Is part of
Biomedicines, 2022, vol. 10, no 1Funder Name
Generalitat Valenciana | Instituto de Salud Carlos III | Ministerio de Economía y Competitividad (España) | Ministerio de Ciencia, Innovación y Universidades | Universitat Jaume I | Rei Jaume I Award for Medical Research 2018 | US Department of Agriculture, Agriculture Research Service
Funder ID
http://dx.doi.org/10.13039/501100003329 | http://dx.doi.org/10.13039/501100011033
Project code
PROMETEO 17/2017 | PROMETEO/2021/021 | APOSTD/2019/136 | APOSTD/2020/164 | CIBER 06/03 | PI06/1326 | PI13/00728 | PI16/00366 | PI19/00781 | MINECO/ICTI2013-2016/SAF2016–80532-R | MICIU/ICTI2017-2020/PID2019-108858RB-I00 | UJI-B2018-69 | COGRUP/2016/06 | 8050-51000-098-00D
Project title or grant
Análisis de un nuevo rol de endoglina en adhesión celular y su relevancia en la biología vascular | Estilo de vida, ómicas y autofagia para un cerebro sano en un cuerpo sano y un envejecimiento saludable: Análisis observacionales y de intervención en población mediterránea
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info:eu-repo/semantics/openAccess
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