Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity
Ver/ Abrir
Impacto
Scholar |
Otros documentos de la autoría: Gallego Villarejo, Lucia; Wallin, Cecilia; Król, Sylwia; Enrich Bengoa, Jennifer; Suades, Albert; Aguilella-Arzo, Marcel; Gómara Elena, María José; Haro, Isabel; Wärmlander, Sebastian; Muñoz, Francisco J.; Gräslund, Astrid; Perálvarez-Marín, Alex
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/2507
comunitat-uji-handle3:10234/6973
comunitat-uji-handle4:
INVESTIGACIONMetadatos
Título
Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicityAutoría
Fecha de publicación
2022Editor
ElsevierISSN
2001-0370Cita bibliográfica
Gallego-Villarejo L, Wallin C, Król S, Enrich-Bengoa J, Suades A, Aguilella-Arzo M, Gomara MJ, Haro I, Wärmlander S, Muñoz FJ, Gräslund A, Perálvarez-Marín A. Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity. Comput Struct Biotechnol J. 2022 Oct 14;20:5672-9. DOI: 10.1016/j.csbj.2022.10.014Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.sciencedirect.com/science/article/pii/S2001037022004615?via%3DihubVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Amyloid β-peptide (Aβ) misfolding into β-sheet structures triggers neurotoxicity inducing Alzheimer’s disease (AD). Molecules able to reduce or to impair Aβ aggregation are highly relevant as possible AD treatments ... [+]
Amyloid β-peptide (Aβ) misfolding into β-sheet structures triggers neurotoxicity inducing Alzheimer’s disease (AD). Molecules able to reduce or to impair Aβ aggregation are highly relevant as possible AD treatments since they should protect against Aβ neurotoxicity. We have studied the effects of the interaction of dynorphins, a family of opioid neuropeptides, with Aβ40 the most abundant species of Aβ. Biophysical measurements indicate that Aβ40 interacts with Big Dynorphin (BigDyn), lowering the amount of hydrophobic aggregates, and slowing down the aggregation kinetics. As expected, we found that BigDyn protects against Aβ40 aggregates when studied in human neuroblastoma cells by cell survival assays. The cross-interaction between BigDyn and Aβ40 provides insight into the mechanism of amyloid pathophysiology and may open up new therapy possibilities. [-]
Publicado en
Computational and structural biotechnology journal, 2022, vol. 20Entidad financiadora
Ministerio de Ciencia, Innovación y Universidades | Generalitat Valenciana
Identificador de la entidad financiadora
http://dx.doi.org/10.13039/501100011033
Código del proyecto o subvención
MICIU/ICTI2017-2020/PID2019-108434GB-I00 | MICIU/ICTI2017-2020/PID2020-120222GB-I00 | MICIU/ICTI2017-2020/PID2020-117691RB-I00 | AICO/2020/066 | CEX2018-000792-M
Título del proyecto o subvención
Estudio biofísico de los mecanismos de permeabilización de membranas inducidos por canales iónicos | Determinantes moleculares en canales iónicos: desde formación de poros a identificación de fármacos basada en ligandos
Derechos de acceso
info:eu-repo/semantics/openAccess
Aparece en las colecciones
- FCA_Articles [510]